PH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization

Jiong Zou; Goran Jafr; Efrosyni Themistou; Yoonsing Yap; Zachary A.P. Wintrob; Paschalis Alexandridis; Alice C. Ceacareanu; Chong Cheng

doi:10.1039/c0cc05531j

PH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization

Jiong Zou
, Goran Jafr
, Efrosyni Themistou
, Yoonsing Yap
, Zachary A.P. Wintrob
, Paschalis Alexandridis
, Alice C. Ceacareanu
, Chong Cheng

Department of Chemical and Biological Engineering

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

Representing a new category of polymer-drug conjugates, brush polymer-drug conjugates were prepared by ring-opening metathesis copolymerization. Following judicious structural design, these conjugates exhibited well-shielded drug moieties, significant water solubility, well-defined nanostructures, and acid-triggered drug release.

Original language	English
Pages (from-to)	4493-4495
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	15
DOIs	https://doi.org/10.1039/c0cc05531j
State	Published - Mar 29 2011

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title = "PH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization",

abstract = "Representing a new category of polymer-drug conjugates, brush polymer-drug conjugates were prepared by ring-opening metathesis copolymerization. Following judicious structural design, these conjugates exhibited well-shielded drug moieties, significant water solubility, well-defined nanostructures, and acid-triggered drug release.",

author = "Jiong Zou and Goran Jafr and Efrosyni Themistou and Yoonsing Yap and Wintrob, \{Zachary A.P.\} and Paschalis Alexandridis and Ceacareanu, \{Alice C.\} and Chong Cheng",

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doi = "10.1039/c0cc05531j",

language = "English",

volume = "47",

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journal = "Chemical Communications",

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AU - Zou, Jiong

AU - Jafr, Goran

AU - Themistou, Efrosyni

AU - Yap, Yoonsing

AU - Wintrob, Zachary A.P.

AU - Alexandridis, Paschalis

AU - Ceacareanu, Alice C.

AU - Cheng, Chong

PY - 2011/3/29

Y1 - 2011/3/29

N2 - Representing a new category of polymer-drug conjugates, brush polymer-drug conjugates were prepared by ring-opening metathesis copolymerization. Following judicious structural design, these conjugates exhibited well-shielded drug moieties, significant water solubility, well-defined nanostructures, and acid-triggered drug release.

AB - Representing a new category of polymer-drug conjugates, brush polymer-drug conjugates were prepared by ring-opening metathesis copolymerization. Following judicious structural design, these conjugates exhibited well-shielded drug moieties, significant water solubility, well-defined nanostructures, and acid-triggered drug release.

UR - https://www.scopus.com/pages/publications/79955034143

U2 - 10.1039/c0cc05531j

DO - 10.1039/c0cc05531j

M3 - Article

C2 - 21399797

AN - SCOPUS:79955034143

SN - 1359-7345

VL - 47

SP - 4493

EP - 4495

JO - Chemical Communications

JF - Chemical Communications

IS - 15

ER -

PH-Sensitive brush polymer-drug conjugates by ring-opening metathesis copolymerization

Abstract

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