Abstract
Animal development proceeds through the activity of genes and their cis-regulatory modules (CRMs) working together in sets of gene regulatory networks (GRNs). The emergence of species-specific traits and novel structures results from evolutionary changes in GRNs. Recent work in a wide variety of animal models, and particularly in insects, has started to reveal the modes and mechanisms of GRN evolution. I discuss here various aspects of GRN evolution and argue that developmental system drift (DSD), in which conserved phenotype is nevertheless a result of changed genetic interactions, should regularly be viewed from the perspective of GRN evolution. Advances in methods to discover related CRMs in diverse insect species, a critical requirement for detailed GRN characterization, are also described.
| Original language | English |
|---|---|
| Pages (from-to) | 436-447 |
| Number of pages | 12 |
| Journal | Trends in Genetics |
| Volume | 33 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2017 |
Keywords
- cis-regulatory module
- developmental system drift
- DSD
- enhancer evolution
- evodevo
- GRN
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