PDT in periodontal disease of HAART resistance patients

Elcio M. Giovani; Gilberto A. Noro-Filho; Bruno V. Caputo; Renato Casarin; Claudio Costa; Daniela Salgado; Camila C. Santos

doi:10.1117/12.2212804

PDT in periodontal disease of HAART resistance patients

Elcio M. Giovani
, Gilberto A. Noro-Filho
, Bruno V. Caputo
, Renato Casarin
, Claudio Costa
, Daniela Salgado
, Camila C. Santos

Department of Periodontics and Endodontics

Universidade Paulista

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

HIV/Aids patients present a change of microbiota associated with host immunodeficiency. Photodynamic therapy (PDT) showed as a promising and viable alternative in reducing microbiota. Present study evaluate effectiveness of photodynamic therapy in periodontal disease of AIDS patients with highly activity antiretroviral therapy (HAART) failure, measuring the clinical periodontal parameters and periodontal microbiota. Twelve patients with HARRT resistance (R group) divided into two groups (control and PDT) and 12 patients with no HAART resistance (NR group) divided into two groups (control and PDT). The results show the difference in baseline of CD4 cells count, NR group 640.0 ± 176.2 cells/mm³ R group and 333.3 ± 205.8 cells/mm³ (p<0.05), and in 8.3% detectable viral load in NR group and 75% detectable (p <0.001) in R group. As clinical periodontal parameters (PD and CAL), PDT was more effective than the control group only in the NR group (p <0.05%), moreover, there was no difference in the evaluation of clinical periodontal parameters between the both R groups (p>0.05%). Microbiological evaluation in R group presents a general reduction in the Aa at 3 and 6 months. Furthermore, demonstrated a reduction of Pg in all groups at 6 months and in R group at 3 months. The impact assessment of photodynamic therapy in patients with different levels of immunosuppression determined that the combination of mechanical periodontal treatment with photodynamic therapy in patients with HAART failure did not cause additional benefits. Therefore, PDT in this study could not been indicated in HAART resistance patients.

Original language	English
Title of host publication	Mechanisms of Photobiomodulation Therapy XI
Editors	Michael R. Hamblin, James D. Carroll, Praveen Arany
Publisher	SPIE
ISBN (Electronic)	9781628419290
DOIs	https://doi.org/10.1117/12.2212804
State	Published - 2016
Event	Mechanisms of Photobiomodulation Therapy XI - San Francisco, United States Duration: Feb 13 2016 → Feb 14 2016

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9695
ISSN (Print)	1605-7422

Conference

Conference	Mechanisms of Photobiomodulation Therapy XI
Country/Territory	United States
City	San Francisco
Period	02/13/16 → 02/14/16

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10.1117/12.2212804

Cite this

Giovani, E. M., Noro-Filho, G. A., Caputo, B. V., Casarin, R., Costa, C., Salgado, D., & Santos, C. C. (2016). PDT in periodontal disease of HAART resistance patients. In M. R. Hamblin, J. D. Carroll, & P. Arany (Eds.), Mechanisms of Photobiomodulation Therapy XI Article 96950S (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9695). SPIE. https://doi.org/10.1117/12.2212804

@inproceedings{05f6a66b0faf4a15a65672fde811b8c5,

title = "PDT in periodontal disease of HAART resistance patients",

abstract = "HIV/Aids patients present a change of microbiota associated with host immunodeficiency. Photodynamic therapy (PDT) showed as a promising and viable alternative in reducing microbiota. Present study evaluate effectiveness of photodynamic therapy in periodontal disease of AIDS patients with highly activity antiretroviral therapy (HAART) failure, measuring the clinical periodontal parameters and periodontal microbiota. Twelve patients with HARRT resistance (R group) divided into two groups (control and PDT) and 12 patients with no HAART resistance (NR group) divided into two groups (control and PDT). The results show the difference in baseline of CD4 cells count, NR group 640.0 ± 176.2 cells/mm3 R group and 333.3 ± 205.8 cells/mm3 (p<0.05), and in 8.3\% detectable viral load in NR group and 75\% detectable (p <0.001) in R group. As clinical periodontal parameters (PD and CAL), PDT was more effective than the control group only in the NR group (p <0.05\%), moreover, there was no difference in the evaluation of clinical periodontal parameters between the both R groups (p>0.05\%). Microbiological evaluation in R group presents a general reduction in the Aa at 3 and 6 months. Furthermore, demonstrated a reduction of Pg in all groups at 6 months and in R group at 3 months. The impact assessment of photodynamic therapy in patients with different levels of immunosuppression determined that the combination of mechanical periodontal treatment with photodynamic therapy in patients with HAART failure did not cause additional benefits. Therefore, PDT in this study could not been indicated in HAART resistance patients.",

author = "Giovani, \{Elcio M.\} and Noro-Filho, \{Gilberto A.\} and Caputo, \{Bruno V.\} and Renato Casarin and Claudio Costa and Daniela Salgado and Santos, \{Camila C.\}",

note = "Publisher Copyright: {\textcopyright} 2016 SPIE.; Mechanisms of Photobiomodulation Therapy XI ; Conference date: 13-02-2016 Through 14-02-2016",

year = "2016",

doi = "10.1117/12.2212804",

language = "English",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Hamblin, \{Michael R.\} and Carroll, \{James D.\} and Praveen Arany",

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address = "United States",

}

Giovani, EM, Noro-Filho, GA, Caputo, BV, Casarin, R, Costa, C, Salgado, D & Santos, CC 2016, PDT in periodontal disease of HAART resistance patients. in MR Hamblin, JD Carroll & P Arany (eds), Mechanisms of Photobiomodulation Therapy XI., 96950S, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9695, SPIE, Mechanisms of Photobiomodulation Therapy XI, San Francisco, United States, 02/13/16. https://doi.org/10.1117/12.2212804

PDT in periodontal disease of HAART resistance patients. / Giovani, Elcio M.; Noro-Filho, Gilberto A.; Caputo, Bruno V. et al.
Mechanisms of Photobiomodulation Therapy XI. ed. / Michael R. Hamblin; James D. Carroll; Praveen Arany. SPIE, 2016. 96950S (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9695).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - PDT in periodontal disease of HAART resistance patients

AU - Giovani, Elcio M.

AU - Noro-Filho, Gilberto A.

AU - Caputo, Bruno V.

AU - Casarin, Renato

AU - Costa, Claudio

AU - Salgado, Daniela

AU - Santos, Camila C.

PY - 2016

Y1 - 2016

N2 - HIV/Aids patients present a change of microbiota associated with host immunodeficiency. Photodynamic therapy (PDT) showed as a promising and viable alternative in reducing microbiota. Present study evaluate effectiveness of photodynamic therapy in periodontal disease of AIDS patients with highly activity antiretroviral therapy (HAART) failure, measuring the clinical periodontal parameters and periodontal microbiota. Twelve patients with HARRT resistance (R group) divided into two groups (control and PDT) and 12 patients with no HAART resistance (NR group) divided into two groups (control and PDT). The results show the difference in baseline of CD4 cells count, NR group 640.0 ± 176.2 cells/mm3 R group and 333.3 ± 205.8 cells/mm3 (p<0.05), and in 8.3% detectable viral load in NR group and 75% detectable (p <0.001) in R group. As clinical periodontal parameters (PD and CAL), PDT was more effective than the control group only in the NR group (p <0.05%), moreover, there was no difference in the evaluation of clinical periodontal parameters between the both R groups (p>0.05%). Microbiological evaluation in R group presents a general reduction in the Aa at 3 and 6 months. Furthermore, demonstrated a reduction of Pg in all groups at 6 months and in R group at 3 months. The impact assessment of photodynamic therapy in patients with different levels of immunosuppression determined that the combination of mechanical periodontal treatment with photodynamic therapy in patients with HAART failure did not cause additional benefits. Therefore, PDT in this study could not been indicated in HAART resistance patients.

AB - HIV/Aids patients present a change of microbiota associated with host immunodeficiency. Photodynamic therapy (PDT) showed as a promising and viable alternative in reducing microbiota. Present study evaluate effectiveness of photodynamic therapy in periodontal disease of AIDS patients with highly activity antiretroviral therapy (HAART) failure, measuring the clinical periodontal parameters and periodontal microbiota. Twelve patients with HARRT resistance (R group) divided into two groups (control and PDT) and 12 patients with no HAART resistance (NR group) divided into two groups (control and PDT). The results show the difference in baseline of CD4 cells count, NR group 640.0 ± 176.2 cells/mm3 R group and 333.3 ± 205.8 cells/mm3 (p<0.05), and in 8.3% detectable viral load in NR group and 75% detectable (p <0.001) in R group. As clinical periodontal parameters (PD and CAL), PDT was more effective than the control group only in the NR group (p <0.05%), moreover, there was no difference in the evaluation of clinical periodontal parameters between the both R groups (p>0.05%). Microbiological evaluation in R group presents a general reduction in the Aa at 3 and 6 months. Furthermore, demonstrated a reduction of Pg in all groups at 6 months and in R group at 3 months. The impact assessment of photodynamic therapy in patients with different levels of immunosuppression determined that the combination of mechanical periodontal treatment with photodynamic therapy in patients with HAART failure did not cause additional benefits. Therefore, PDT in this study could not been indicated in HAART resistance patients.

UR - https://www.scopus.com/pages/publications/84978670479

U2 - 10.1117/12.2212804

DO - 10.1117/12.2212804

M3 - Conference contribution

AN - SCOPUS:84978670479

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Mechanisms of Photobiomodulation Therapy XI

A2 - Hamblin, Michael R.

A2 - Carroll, James D.

A2 - Arany, Praveen

PB - SPIE

T2 - Mechanisms of Photobiomodulation Therapy XI

Y2 - 13 February 2016 through 14 February 2016

ER -

PDT in periodontal disease of HAART resistance patients

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