Abstract
Monkey testicular homogenates and minces were incubated for varying lengths of time with pairs of differentially labelled steroids, progesterone and pregnenolone, 17α-hydroxyprogesterone and 17α-hydroxypregnenolone and androstenedione and dehydroepiandrosterone, in order to elucidate the possible pathways involved in testosterone biosynthesis. It was evident that all these steroids could be converted to testosterone but pregnenolone and 17α-hydroxy-pregnenolone were better precursors than progesterone and 17α-hydroxypro-gesterone. The results suggest that testosterone is made from pregnenolone and 17α-hydroxypregnenolone by a pathway independent of androstenedione. Δ5-Androstenediol must be considered as a possible intermediate in testosterone biosynthesis having been formed from both pregnenolone and 17α-hydroxypreg-nenolone.
| Original language | English |
|---|---|
| Pages (from-to) | 49-69 |
| Number of pages | 21 |
| Journal | Steroids |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1967 |
Keywords
- 11-Deoxycorticosterone acetate
- 17α-Hydroxypregnenolone
- 17β-hydroxyandrost-4-en-3-one
- 20-dione 17α-Hydroxyprogesterone
- 21-acetoxypregn-4-en-3, 20-dione
- 3β-17α-dihydroxypregn-5-en-20-one
- 3β-hydroxyandrost-5-en-17-one
- 3β-hydroxypregn-5-en-20-one
- 7α-hydroxypregn-4-en-3, 20-dione
- androst-4-en-3, 17-dione
- androst-5-en-3β, 17β-diol
- Androstenedione
- Dehydroepiandrosterone (DHEA)
- pregn-4-en-3
- Pregnenolone
- Progesterone
- Testosterone
- Δ-Androstenediol
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