Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation

Victor Y. Fujimoto; Richard W. Browne; Michael S. Bloom; Denny Sakkas; Mina Alikani

doi:10.1016/j.fertnstert.2010.11.033

Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation

Victor Y. Fujimoto
, Richard W. Browne
, Michael S. Bloom
, Denny Sakkas
, Mina Alikani

Biotechnical and Clinical Laboratory Sciences

University of California at San Francisco
SUNY Albany
Yale University
Tyho-Galileo Research Laboratories

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

This narrative review summarizes the current state of knowledge about human embryo fragmentation during IVF. The clinical relevance of fragmentation is discussed and evidence supporting a central role for the oocyte in the pathogenesis of fragmentation is presented. A mechanism of fragmentation as aberrant cell division involving the cytoskeleton is described along with the novel concept of membrane instability in relation to follicular high-density lipoprotein metabolism and cholesterol transport.

Original language	English
Pages (from-to)	1197-1204
Number of pages	8
Journal	Fertility and Sterility
Volume	95
Issue number	4
DOIs	https://doi.org/10.1016/j.fertnstert.2010.11.033
State	Published - Mar 15 2011

Keywords

apoptosis
cytoskeleton
Embryo fragmentation
follicular fluid cholesterol
HDL metabolism
oocyte quality

Access to Document

10.1016/j.fertnstert.2010.11.033

Cite this

@article{3141197f77ed41398ba8cf1986517bed,

title = "Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation",

abstract = "This narrative review summarizes the current state of knowledge about human embryo fragmentation during IVF. The clinical relevance of fragmentation is discussed and evidence supporting a central role for the oocyte in the pathogenesis of fragmentation is presented. A mechanism of fragmentation as aberrant cell division involving the cytoskeleton is described along with the novel concept of membrane instability in relation to follicular high-density lipoprotein metabolism and cholesterol transport.",

keywords = "apoptosis, cytoskeleton, Embryo fragmentation, follicular fluid cholesterol, HDL metabolism, oocyte quality",

author = "Fujimoto, \{Victor Y.\} and Browne, \{Richard W.\} and Bloom, \{Michael S.\} and Denny Sakkas and Mina Alikani",

year = "2011",

month = mar,

day = "15",

doi = "10.1016/j.fertnstert.2010.11.033",

language = "English",

volume = "95",

pages = "1197--1204",

journal = "Fertility and Sterility",

issn = "0015-0282",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation

AU - Fujimoto, Victor Y.

AU - Browne, Richard W.

AU - Bloom, Michael S.

AU - Sakkas, Denny

AU - Alikani, Mina

PY - 2011/3/15

Y1 - 2011/3/15

N2 - This narrative review summarizes the current state of knowledge about human embryo fragmentation during IVF. The clinical relevance of fragmentation is discussed and evidence supporting a central role for the oocyte in the pathogenesis of fragmentation is presented. A mechanism of fragmentation as aberrant cell division involving the cytoskeleton is described along with the novel concept of membrane instability in relation to follicular high-density lipoprotein metabolism and cholesterol transport.

AB - This narrative review summarizes the current state of knowledge about human embryo fragmentation during IVF. The clinical relevance of fragmentation is discussed and evidence supporting a central role for the oocyte in the pathogenesis of fragmentation is presented. A mechanism of fragmentation as aberrant cell division involving the cytoskeleton is described along with the novel concept of membrane instability in relation to follicular high-density lipoprotein metabolism and cholesterol transport.

KW - apoptosis

KW - cytoskeleton

KW - Embryo fragmentation

KW - follicular fluid cholesterol

KW - HDL metabolism

KW - oocyte quality

UR - https://www.scopus.com/pages/publications/79952448231

U2 - 10.1016/j.fertnstert.2010.11.033

DO - 10.1016/j.fertnstert.2010.11.033

M3 - Article

C2 - 21146166

AN - SCOPUS:79952448231

SN - 0015-0282

VL - 95

SP - 1197

EP - 1204

JO - Fertility and Sterility

JF - Fertility and Sterility

IS - 4

ER -

Pathogenesis, developmental consequences, and clinical correlations of human embryo fragmentation

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this