PASSIVE IMMUNISATION WITH SERUM AND IMMUNOGLOBULINS AGAINST DENTAL CARIES IN RHESUS MONKEYS

T. Lehner; S. J. Challacombe; M. W. Russell; C. M. Scully; Jane E. Hawkes

doi:10.1016/S0140-6736(78)90803-6

PASSIVE IMMUNISATION WITH SERUM AND IMMUNOGLOBULINS AGAINST DENTAL CARIES IN RHESUS MONKEYS

T. Lehner
, S. J. Challacombe
, M. W. Russell
, C. M. Scully
, Jane E. Hawkes

Microbiology and Immunology

King's College London

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Active immunisation with Streptococcus mutans induced protection against dental caries in rhesus monkeys, and this was associated with serum antibodies. Passive transfer of immune serum with IgG, IgM, and IgA antibodies to Strep. mutans failed to induce protection against dental caries. However, when separated IgG, IgM, and IgA sera were given, IgG induced significant protection but IgA or IgM antibodies to Strep. mutans did not. IgA and IgM may compete or interfere with the protective effect of IgG antibodies, and the ratio of IgG/IgA and IgG/IgM antibodies might be an important factor in immunisation against dental caries.

Original language	English
Pages (from-to)	693-695
Number of pages	3
Journal	The Lancet
Volume	311
Issue number	8066
DOIs	https://doi.org/10.1016/S0140-6736(78)90803-6
State	Published - Apr 1 1978

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title = "PASSIVE IMMUNISATION WITH SERUM AND IMMUNOGLOBULINS AGAINST DENTAL CARIES IN RHESUS MONKEYS",

abstract = "Active immunisation with Streptococcus mutans induced protection against dental caries in rhesus monkeys, and this was associated with serum antibodies. Passive transfer of immune serum with IgG, IgM, and IgA antibodies to Strep. mutans failed to induce protection against dental caries. However, when separated IgG, IgM, and IgA sera were given, IgG induced significant protection but IgA or IgM antibodies to Strep. mutans did not. IgA and IgM may compete or interfere with the protective effect of IgG antibodies, and the ratio of IgG/IgA and IgG/IgM antibodies might be an important factor in immunisation against dental caries.",

author = "T. Lehner and Challacombe, \{S. J.\} and Russell, \{M. W.\} and Scully, \{C. M.\} and Hawkes, \{Jane E.\}",

year = "1978",

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doi = "10.1016/S0140-6736(78)90803-6",

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AU - Lehner, T.

AU - Challacombe, S. J.

AU - Russell, M. W.

AU - Scully, C. M.

AU - Hawkes, Jane E.

PY - 1978/4/1

Y1 - 1978/4/1

N2 - Active immunisation with Streptococcus mutans induced protection against dental caries in rhesus monkeys, and this was associated with serum antibodies. Passive transfer of immune serum with IgG, IgM, and IgA antibodies to Strep. mutans failed to induce protection against dental caries. However, when separated IgG, IgM, and IgA sera were given, IgG induced significant protection but IgA or IgM antibodies to Strep. mutans did not. IgA and IgM may compete or interfere with the protective effect of IgG antibodies, and the ratio of IgG/IgA and IgG/IgM antibodies might be an important factor in immunisation against dental caries.

AB - Active immunisation with Streptococcus mutans induced protection against dental caries in rhesus monkeys, and this was associated with serum antibodies. Passive transfer of immune serum with IgG, IgM, and IgA antibodies to Strep. mutans failed to induce protection against dental caries. However, when separated IgG, IgM, and IgA sera were given, IgG induced significant protection but IgA or IgM antibodies to Strep. mutans did not. IgA and IgM may compete or interfere with the protective effect of IgG antibodies, and the ratio of IgG/IgA and IgG/IgM antibodies might be an important factor in immunisation against dental caries.

UR - https://www.scopus.com/pages/publications/0017840098

U2 - 10.1016/S0140-6736(78)90803-6

DO - 10.1016/S0140-6736(78)90803-6

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AN - SCOPUS:0017840098

SN - 0140-6736

VL - 311

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EP - 695

JO - The Lancet

JF - The Lancet

IS - 8066

ER -

PASSIVE IMMUNISATION WITH SERUM AND IMMUNOGLOBULINS AGAINST DENTAL CARIES IN RHESUS MONKEYS

Abstract

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