Osteoinductive bone graft substitutes

Steven C. Ludwig; Joseph M. Kowalski; Scott D. Boden

doi:10.1007/pl00008317

Osteoinductive bone graft substitutes

Steven C. Ludwig
, Joseph M. Kowalski
, Scott D. Boden

Orthopaedics

Emory University

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

This review will summarize the major efforts currently underway to develop osteoinductive bone graft substitutes for minimally invasive spine fusions. The primary categories of substitute include purified bone growth factors, recombinant bone growth factors, and growth factors delivered by gene therapy approaches. Clinical trials are underway for the purified and recombinant bone growth factors and pre-clinical studies have yielded promising results for a variety of gene therapy techniques for generating bone.

Original language	English
Pages (from-to)	S119-S125
Journal	European Spine Journal
Volume	9
Issue number	SUPPL.1
DOIs	https://doi.org/10.1007/pl00008317
State	Published - 2000

Keywords

Bone graft substitute
Bone morphogenetic protein
Gene therapy
Spine fusion

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10.1007/pl00008317

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title = "Osteoinductive bone graft substitutes",

abstract = "This review will summarize the major efforts currently underway to develop osteoinductive bone graft substitutes for minimally invasive spine fusions. The primary categories of substitute include purified bone growth factors, recombinant bone growth factors, and growth factors delivered by gene therapy approaches. Clinical trials are underway for the purified and recombinant bone growth factors and pre-clinical studies have yielded promising results for a variety of gene therapy techniques for generating bone.",

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AU - Kowalski, Joseph M.

AU - Boden, Scott D.

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AB - This review will summarize the major efforts currently underway to develop osteoinductive bone graft substitutes for minimally invasive spine fusions. The primary categories of substitute include purified bone growth factors, recombinant bone growth factors, and growth factors delivered by gene therapy approaches. Clinical trials are underway for the purified and recombinant bone growth factors and pre-clinical studies have yielded promising results for a variety of gene therapy techniques for generating bone.

KW - Bone graft substitute

KW - Bone morphogenetic protein

KW - Gene therapy

KW - Spine fusion

UR - https://www.scopus.com/pages/publications/0000844225

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M3 - Article

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Osteoinductive bone graft substitutes

Abstract

Keywords

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