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Oscillations in a simple model of tubuloglomerular feedback

  • Duke University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The tubuloglomerular feedback (TGF) system regulates the fluid and solute load in each nephron of the mammalian kidney. The authors obtain a necessary condition for sustained oscillations in a simple mathematical model for the TGF loop. This model consists of a hyperbolic partial differential equation representing the chloride concentration in the thick ascending limb and an empirical function describing the feedback response of the juxtaglomerular apparatus. A bifurcation analysis shows that critical parameters are the time delay, the slope of the empirical feedback relation at the steady state, and the steady-state space derivative of the chloride concentration at the macula densa.

Original languageEnglish
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Pages987-988
Number of pages2
Editionpt 3
ISBN (Print)0879425598
StatePublished - 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 3
ISSN (Print)0589-1019

Conference

ConferenceProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA
Period11/1/9011/4/90

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