Optic nerve transection decreases 2-[125I]iodomelatonin binding in the chick optic tectum

Diana N. Krause; Judith A. Siuciak; Margarita L. Dubocovich

doi:10.1016/0006-8993(92)91115-U

Optic nerve transection decreases 2-[¹²⁵I]iodomelatonin binding in the chick optic tectum

Diana N. Krause
, Judith A. Siuciak
, Margarita L. Dubocovich

Pharmacology and Toxicology

University of California at Irvine
Northwestern University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The distribution of specific 2-[¹²⁵I]iodomelatonin binding sites in the various layers of the chick optic tectum was analyzed using quantitative receptor autoradiography. Following unilateral optic nerve transection, binding in the optic fiber layer and superficial retinorecipient layers of the contralateral tectum was significantly decreased at 7 and 14 days, but not at 1 day, following transection. The results are consistent with the presence of presynaptic melatonin receptors on axon terminals of retinotectal fibers.

Original language	English
Pages (from-to)	325-328
Number of pages	4
Journal	Brain Research
Volume	590
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(92)91115-U
State	Published - Sep 11 1992

Keywords

2-[I]Iodomelatonin binding
Chick optic tectum
Melatonin
Optic nerve transection
Receptor autoradiography

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10.1016/0006-8993(92)91115-U

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@article{e351377824d14b9a882cc75ec8b3dd6e,

title = "Optic nerve transection decreases 2-[125I]iodomelatonin binding in the chick optic tectum",

abstract = "The distribution of specific 2-[125I]iodomelatonin binding sites in the various layers of the chick optic tectum was analyzed using quantitative receptor autoradiography. Following unilateral optic nerve transection, binding in the optic fiber layer and superficial retinorecipient layers of the contralateral tectum was significantly decreased at 7 and 14 days, but not at 1 day, following transection. The results are consistent with the presence of presynaptic melatonin receptors on axon terminals of retinotectal fibers.",

keywords = "2-[I]Iodomelatonin binding, Chick optic tectum, Melatonin, Optic nerve transection, Receptor autoradiography",

author = "Krause, \{Diana N.\} and Siuciak, \{Judith A.\} and Dubocovich, \{Margarita L.\}",

year = "1992",

month = sep,

day = "11",

doi = "10.1016/0006-8993(92)91115-U",

language = "English",

volume = "590",

pages = "325--328",

journal = "Brain Research",

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TY - JOUR

T1 - Optic nerve transection decreases 2-[125I]iodomelatonin binding in the chick optic tectum

AU - Krause, Diana N.

AU - Siuciak, Judith A.

AU - Dubocovich, Margarita L.

PY - 1992/9/11

Y1 - 1992/9/11

N2 - The distribution of specific 2-[125I]iodomelatonin binding sites in the various layers of the chick optic tectum was analyzed using quantitative receptor autoradiography. Following unilateral optic nerve transection, binding in the optic fiber layer and superficial retinorecipient layers of the contralateral tectum was significantly decreased at 7 and 14 days, but not at 1 day, following transection. The results are consistent with the presence of presynaptic melatonin receptors on axon terminals of retinotectal fibers.

AB - The distribution of specific 2-[125I]iodomelatonin binding sites in the various layers of the chick optic tectum was analyzed using quantitative receptor autoradiography. Following unilateral optic nerve transection, binding in the optic fiber layer and superficial retinorecipient layers of the contralateral tectum was significantly decreased at 7 and 14 days, but not at 1 day, following transection. The results are consistent with the presence of presynaptic melatonin receptors on axon terminals of retinotectal fibers.

KW - 2-[I]Iodomelatonin binding

KW - Chick optic tectum

KW - Melatonin

KW - Optic nerve transection

KW - Receptor autoradiography

UR - https://www.scopus.com/pages/publications/0026746216

U2 - 10.1016/0006-8993(92)91115-U

DO - 10.1016/0006-8993(92)91115-U

M3 - Article

C2 - 1422841

AN - SCOPUS:0026746216

SN - 0006-8993

VL - 590

SP - 325

EP - 328

JO - Brain Research

JF - Brain Research

IS - 1-2

ER -

Optic nerve transection decreases 2-[¹²⁵I]iodomelatonin binding in the chick optic tectum

Abstract

Keywords

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