TY - GEN
T1 - On mobility analysis of functional sites from time lapse microscopic image sequences of living cell nucleus
AU - Mukherjee, Lopamudra
AU - Singh, Vikas
AU - Xu, Jinhui
AU - Malyavantham, Kishore S.
AU - Berezney, Ronald
PY - 2006
Y1 - 2006
N2 - Recent research in biology has indicated correlations between the movement patterns of functional sites (such as replication sites in DNA) and zones of genetic activity within a nucleus. A detailed study and analysis of the motion dynamics of these sites can reveal an interesting insight into their role in DNA replication and function. In this paper, we propose a suite of novel techniques to determine, analyze, and interpret the mobility patterns of functional sites. Our algorithms are based on interesting ideas from theoretical computer science and database theory and provide for the first time the tools to interpret the seemingly stochastic motion patterns of the functional sites within the nucleus in terms of a set of tractable 'patterns' which can then be analyzed to understand their biological significance.
AB - Recent research in biology has indicated correlations between the movement patterns of functional sites (such as replication sites in DNA) and zones of genetic activity within a nucleus. A detailed study and analysis of the motion dynamics of these sites can reveal an interesting insight into their role in DNA replication and function. In this paper, we propose a suite of novel techniques to determine, analyze, and interpret the mobility patterns of functional sites. Our algorithms are based on interesting ideas from theoretical computer science and database theory and provide for the first time the tools to interpret the seemingly stochastic motion patterns of the functional sites within the nucleus in terms of a set of tractable 'patterns' which can then be analyzed to understand their biological significance.
UR - https://www.scopus.com/pages/publications/79551682550
U2 - 10.1007/11866763_71
DO - 10.1007/11866763_71
M3 - Conference contribution
C2 - 17354819
AN - SCOPUS:79551682550
SN - 354044727X
SN - 9783540447276
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 577
EP - 585
BT - Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006 - 9th International Conference, Proceedings
PB - Springer Verlag
T2 - 9th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2006
Y2 - 1 October 2006 through 6 October 2006
ER -