Oligonucleotide dot-blot analysis of HLA-DQβ alleles associated with multiple sclerosis

Animesh A. Sinha; Robert B. Bell; Lawrence Steinman; Hugh O. McDevitt

doi:10.1016/0165-5728(91)90072-F

Oligonucleotide dot-blot analysis of HLA-DQβ alleles associated with multiple sclerosis

Animesh A. Sinha
, Robert B. Bell
, Lawrence Steinman
, Hugh O. McDevitt

Department of Dermatology

Stanford University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Oligonucleotide probes were used to investigate the role of DQβ molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQβ1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.

Original language	English
Pages (from-to)	61-65
Number of pages	5
Journal	Journal of Neuroimmunology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/0165-5728(91)90072-F
State	Published - Apr 1991

Keywords

Genetic susceptibility
Histocompatibility antigen
HLA-DQβ allele
Multiple sclerosis

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10.1016/0165-5728(91)90072-F

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title = "Oligonucleotide dot-blot analysis of HLA-DQβ alleles associated with multiple sclerosis",

abstract = "Oligonucleotide probes were used to investigate the role of DQβ molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQβ1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.",

keywords = "Genetic susceptibility, Histocompatibility antigen, HLA-DQβ allele, Multiple sclerosis",

author = "Sinha, \{Animesh A.\} and Bell, \{Robert B.\} and Lawrence Steinman and McDevitt, \{Hugh O.\}",

year = "1991",

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AU - Sinha, Animesh A.

AU - Bell, Robert B.

AU - Steinman, Lawrence

AU - McDevitt, Hugh O.

PY - 1991/4

Y1 - 1991/4

N2 - Oligonucleotide probes were used to investigate the role of DQβ molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQβ1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.

AB - Oligonucleotide probes were used to investigate the role of DQβ molecules in susceptibility to multiple sclerosis. Although shared amino acid and nucleotide sequences in DQβ1 have been suggested to be critical in disease development, we find that the distribution of sequences corresponding to residues 71-77 is not greater in patients versus controls.

KW - Genetic susceptibility

KW - Histocompatibility antigen

KW - HLA-DQβ allele

KW - Multiple sclerosis

UR - https://www.scopus.com/pages/publications/0025970359

U2 - 10.1016/0165-5728(91)90072-F

DO - 10.1016/0165-5728(91)90072-F

M3 - Article

C2 - 2002091

AN - SCOPUS:0025970359

SN - 0165-5728

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EP - 65

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1

ER -

Oligonucleotide dot-blot analysis of HLA-DQβ alleles associated with multiple sclerosis

Abstract

Keywords

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