Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination

Ajai Tripathi; Christina Volsko; Jessie P. Garcia; Eneritz Agirre; Kevin C. Allan; Paul J. Tesar; Bruce D. Trapp; Goncalo Castelo-Branco; Fraser J. Sim; Ranjan Dutta

doi:10.1016/j.celrep.2019.09.020

Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination

Ajai Tripathi
, Christina Volsko
, Jessie P. Garcia
, Eneritz Agirre
, Kevin C. Allan
, Paul J. Tesar
, Bruce D. Trapp
, Goncalo Castelo-Branco
, Fraser J. Sim
, Ranjan Dutta

Pharmacology and Toxicology

Cleveland Clinic Foundation
SUNY Buffalo
Karolinska Institutet
Case Western Reserve University
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Generation of mature oligodendrocytes (OLs) from its progenitors is a controlled process. In this study, Tripathi et al. describes the role of miR-27a, expressed by oligodendrocyte lineage cells, in affecting multiple stages of this process. While miR-27a is needed for generation of mature OLs, increased levels of miR-27a is detected during demyelination and leads to failed remyelination.

Original language	English
Pages (from-to)	904-919.e9
Journal	Cell Reports
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2019.09.020
State	Published - Oct 22 2019

Keywords

miRNA
multiple sclerosis
oligodendrocyte progenitor cells
remyelination

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10.1016/j.celrep.2019.09.020

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title = "Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination",

abstract = "Generation of mature oligodendrocytes (OLs) from its progenitors is a controlled process. In this study, Tripathi et al. describes the role of miR-27a, expressed by oligodendrocyte lineage cells, in affecting multiple stages of this process. While miR-27a is needed for generation of mature OLs, increased levels of miR-27a is detected during demyelination and leads to failed remyelination.",

keywords = "miRNA, multiple sclerosis, oligodendrocyte progenitor cells, remyelination",

author = "Ajai Tripathi and Christina Volsko and Garcia, \{Jessie P.\} and Eneritz Agirre and Allan, \{Kevin C.\} and Tesar, \{Paul J.\} and Trapp, \{Bruce D.\} and Goncalo Castelo-Branco and Sim, \{Fraser J.\} and Ranjan Dutta",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = oct,

day = "22",

doi = "10.1016/j.celrep.2019.09.020",

language = "English",

volume = "29",

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journal = "Cell Reports",

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TY - JOUR

T1 - Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination

AU - Tripathi, Ajai

AU - Volsko, Christina

AU - Garcia, Jessie P.

AU - Agirre, Eneritz

AU - Allan, Kevin C.

AU - Tesar, Paul J.

AU - Trapp, Bruce D.

AU - Castelo-Branco, Goncalo

AU - Sim, Fraser J.

AU - Dutta, Ranjan

PY - 2019/10/22

Y1 - 2019/10/22

N2 - Generation of mature oligodendrocytes (OLs) from its progenitors is a controlled process. In this study, Tripathi et al. describes the role of miR-27a, expressed by oligodendrocyte lineage cells, in affecting multiple stages of this process. While miR-27a is needed for generation of mature OLs, increased levels of miR-27a is detected during demyelination and leads to failed remyelination.

AB - Generation of mature oligodendrocytes (OLs) from its progenitors is a controlled process. In this study, Tripathi et al. describes the role of miR-27a, expressed by oligodendrocyte lineage cells, in affecting multiple stages of this process. While miR-27a is needed for generation of mature OLs, increased levels of miR-27a is detected during demyelination and leads to failed remyelination.

KW - miRNA

KW - multiple sclerosis

KW - oligodendrocyte progenitor cells

KW - remyelination

UR - https://www.scopus.com/pages/publications/85073525379

U2 - 10.1016/j.celrep.2019.09.020

DO - 10.1016/j.celrep.2019.09.020

M3 - Article

C2 - 31644912

AN - SCOPUS:85073525379

SN - 2639-1856

VL - 29

SP - 904-919.e9

JO - Cell Reports

JF - Cell Reports

IS - 4

ER -

Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination

Abstract

Keywords

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