Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors

H. Peng; J. Moffett; J. Myers; X. Fang; E. K. Stachowiak; P. Maher; E. Kratz; J. Hines; S. J. Fluharty; E. Mizukoshi; D. C. Bloom; M. K. Stachowiak

doi:10.1091/mbc.12.2.449

Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors

H. Peng
, J. Moffett
, J. Myers
, X. Fang
, E. K. Stachowiak
, P. Maher
, E. Kratz
, J. Hines
, S. J. Fluharty
, E. Mizukoshi
, D. C. Bloom
, M. K. Stachowiak

Department of Pathology and Anatomical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1′,3′-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.

Original language	English
Pages (from-to)	449-462
Number of pages	14
Journal	Molecular Biology of the Cell
Volume	12
Issue number	2
DOIs	https://doi.org/10.1091/mbc.12.2.449
State	Published - 2001

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Peng, H., Moffett, J., Myers, J., Fang, X., Stachowiak, E. K., Maher, P., Kratz, E., Hines, J., Fluharty, S. J., Mizukoshi, E., Bloom, D. C., & Stachowiak, M. K. (2001). Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors. Molecular Biology of the Cell, 12(2), 449-462. https://doi.org/10.1091/mbc.12.2.449

@article{9e33b3e340ff46f6ab81d70057cac188,

title = "Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors",

abstract = "In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1′,3′-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.",

author = "H. Peng and J. Moffett and J. Myers and X. Fang and Stachowiak, \{E. K.\} and P. Maher and E. Kratz and J. Hines and Fluharty, \{S. J.\} and E. Mizukoshi and Bloom, \{D. C.\} and Stachowiak, \{M. K.\}",

year = "2001",

doi = "10.1091/mbc.12.2.449",

language = "English",

volume = "12",

pages = "449--462",

journal = "Molecular Biology of the Cell",

issn = "1059-1524",

publisher = "American Society for Cell Biology",

number = "2",

}

Peng, H, Moffett, J, Myers, J, Fang, X, Stachowiak, EK, Maher, P, Kratz, E, Hines, J, Fluharty, SJ, Mizukoshi, E, Bloom, DC & Stachowiak, MK 2001, 'Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors', Molecular Biology of the Cell, vol. 12, no. 2, pp. 449-462. https://doi.org/10.1091/mbc.12.2.449

TY - JOUR

T1 - Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors

AU - Peng, H.

AU - Moffett, J.

AU - Myers, J.

AU - Fang, X.

AU - Stachowiak, E. K.

AU - Maher, P.

AU - Kratz, E.

AU - Hines, J.

AU - Fluharty, S. J.

AU - Mizukoshi, E.

AU - Bloom, D. C.

AU - Stachowiak, M. K.

PY - 2001

Y1 - 2001

N2 - In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1′,3′-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.

AB - In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type 1 and type 2 AII receptors and the downstream cyclic adenosine 1′,3′-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.

UR - https://www.scopus.com/pages/publications/0035149698

U2 - 10.1091/mbc.12.2.449

DO - 10.1091/mbc.12.2.449

M3 - Article

C2 - 11179427

AN - SCOPUS:0035149698

SN - 1059-1524

VL - 12

SP - 449

EP - 462

JO - Molecular Biology of the Cell

JF - Molecular Biology of the Cell

IS - 2

ER -

Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors

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