Normal volume of distribution of tobramycin in a mother and daughter with a CFTR splice mutation (1717 - 1G → A)

Dawn Simon; Michael Cimino; Drucy Borowitz

doi:10.1002/ppul.10072

Normal volume of distribution of tobramycin in a mother and daughter with a CFTR splice mutation (1717 - 1G → A)

Dawn Simon
, Michael Cimino
, Drucy Borowitz

Pediatrics

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A mother and daughter pair with CF who shared a splice mutation (1717 - 1G → A) had a normal volume of distribution of tobramycin. The literature on tobramycin pharmacokinetics, which was published before the genetic defect was identified, is discussed. The authors speculate on the role of CFTR in the distribution of aminoglycosides and recommend that CFTR mutations should be clarified in all future studies of tobramycin pharmacokinetics in patients with CF.

Original language	English
Pages (from-to)	315-317
Number of pages	3
Journal	Pediatric Pulmonology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1002/ppul.10072
State	Published - 2002

Keywords

Aminoglycosides
CFTR mutations
Cystic fibrosis
Pharmacokinetics
Tobramycin

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10.1002/ppul.10072

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abstract = "A mother and daughter pair with CF who shared a splice mutation (1717 - 1G → A) had a normal volume of distribution of tobramycin. The literature on tobramycin pharmacokinetics, which was published before the genetic defect was identified, is discussed. The authors speculate on the role of CFTR in the distribution of aminoglycosides and recommend that CFTR mutations should be clarified in all future studies of tobramycin pharmacokinetics in patients with CF.",

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AU - Cimino, Michael

AU - Borowitz, Drucy

PY - 2002

Y1 - 2002

N2 - A mother and daughter pair with CF who shared a splice mutation (1717 - 1G → A) had a normal volume of distribution of tobramycin. The literature on tobramycin pharmacokinetics, which was published before the genetic defect was identified, is discussed. The authors speculate on the role of CFTR in the distribution of aminoglycosides and recommend that CFTR mutations should be clarified in all future studies of tobramycin pharmacokinetics in patients with CF.

AB - A mother and daughter pair with CF who shared a splice mutation (1717 - 1G → A) had a normal volume of distribution of tobramycin. The literature on tobramycin pharmacokinetics, which was published before the genetic defect was identified, is discussed. The authors speculate on the role of CFTR in the distribution of aminoglycosides and recommend that CFTR mutations should be clarified in all future studies of tobramycin pharmacokinetics in patients with CF.

KW - Aminoglycosides

KW - CFTR mutations

KW - Cystic fibrosis

KW - Pharmacokinetics

KW - Tobramycin

UR - https://www.scopus.com/pages/publications/0036209129

U2 - 10.1002/ppul.10072

DO - 10.1002/ppul.10072

M3 - Article

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AN - SCOPUS:0036209129

SN - 8755-6863

VL - 33

SP - 315

EP - 317

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

IS - 4

ER -

Normal volume of distribution of tobramycin in a mother and daughter with a CFTR splice mutation (1717 - 1G → A)

Abstract

Keywords

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