Nonlinear assessment of phenytoin bioavailability

William J. Jusko; Jeffrey R. Koup; Gunnar Alván

doi:10.1007/BF01063122

Nonlinear assessment of phenytoin bioavailability

William J. Jusko
, Jeffrey R. Koup
, Gunnar Alván

Pharmaceutical Sciences

SUNY Buffalo
Karolinska Institutet

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

The bioavailability of phenytoin, a drug subject to capacity-limited disposition, was examined using linear and nonlinear pharmacokinetic techniques. The linear method (comparative areas) underestimates the essentially complete bioavailability of this drug from capsules (Epanutin, Parke-Davis). The error incurred in using area ratios is inversely related to the rate of absorption of the drug. The time course of absorption of phenytoin capsules is irregular and prolonged over nearly 2 days.

Original language	English
Pages (from-to)	327-336
Number of pages	10
Journal	Journal of Pharmacokinetics and Biopharmaceutics
Volume	4
Issue number	4
DOIs	https://doi.org/10.1007/BF01063122
State	Published - Aug 1976

Keywords

bioavailability
capacity-limited elimination
phenytoin

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10.1007/BF01063122

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title = "Nonlinear assessment of phenytoin bioavailability",

abstract = "The bioavailability of phenytoin, a drug subject to capacity-limited disposition, was examined using linear and nonlinear pharmacokinetic techniques. The linear method (comparative areas) underestimates the essentially complete bioavailability of this drug from capsules (Epanutin, Parke-Davis). The error incurred in using area ratios is inversely related to the rate of absorption of the drug. The time course of absorption of phenytoin capsules is irregular and prolonged over nearly 2 days.",

keywords = "bioavailability, capacity-limited elimination, phenytoin",

author = "Jusko, \{William J.\} and Koup, \{Jeffrey R.\} and Gunnar Alv{\'a}n",

year = "1976",

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journal = "Journal of Pharmacokinetics and Biopharmaceutics",

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T1 - Nonlinear assessment of phenytoin bioavailability

AU - Jusko, William J.

AU - Koup, Jeffrey R.

AU - Alván, Gunnar

PY - 1976/8

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N2 - The bioavailability of phenytoin, a drug subject to capacity-limited disposition, was examined using linear and nonlinear pharmacokinetic techniques. The linear method (comparative areas) underestimates the essentially complete bioavailability of this drug from capsules (Epanutin, Parke-Davis). The error incurred in using area ratios is inversely related to the rate of absorption of the drug. The time course of absorption of phenytoin capsules is irregular and prolonged over nearly 2 days.

AB - The bioavailability of phenytoin, a drug subject to capacity-limited disposition, was examined using linear and nonlinear pharmacokinetic techniques. The linear method (comparative areas) underestimates the essentially complete bioavailability of this drug from capsules (Epanutin, Parke-Davis). The error incurred in using area ratios is inversely related to the rate of absorption of the drug. The time course of absorption of phenytoin capsules is irregular and prolonged over nearly 2 days.

KW - bioavailability

KW - capacity-limited elimination

KW - phenytoin

UR - https://www.scopus.com/pages/publications/0017213273

U2 - 10.1007/BF01063122

DO - 10.1007/BF01063122

M3 - Article

C2 - 978395

AN - SCOPUS:0017213273

SN - 0090-466X

VL - 4

SP - 327

EP - 336

JO - Journal of Pharmacokinetics and Biopharmaceutics

JF - Journal of Pharmacokinetics and Biopharmaceutics

IS - 4

ER -

Nonlinear assessment of phenytoin bioavailability

Abstract

Keywords

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