Non-Stem Cell Origin for Oligodendroglioma

Anders I. Persson; Claudia Petritsch; Fredrik J. Swartling; Melissa Itsara; Fraser J. Sim; Romane Auvergne; David D. Goldenberg; Scott R. Vandenberg; Kim N. Nguyen; Stanislava Yakovenko; Jennifer Ayers-Ringler; Akiko Nishiyama; William B. Stallcup; Mitchel S. Berger; Gabriele Bergers; Tracy R. McKnight; Steven A. Goldman; William A. Weiss

doi:10.1016/j.ccr.2010.10.033

Non-Stem Cell Origin for Oligodendroglioma

Anders I. Persson
, Claudia Petritsch
, Fredrik J. Swartling
, Melissa Itsara
, Fraser J. Sim
, Romane Auvergne
, David D. Goldenberg
, Scott R. Vandenberg
, Kim N. Nguyen
, Stanislava Yakovenko
, Jennifer Ayers-Ringler
, Akiko Nishiyama
, William B. Stallcup
, Mitchel S. Berger
, Gabriele Bergers
, Tracy R. McKnight
, Steven A. Goldman
, William A. Weiss

Pharmacology and Toxicology

University of California at San Francisco
University of Rochester
University of Connecticut
Sanford Burnham Prebys Medical Discovery Institute

Research output: Contribution to journal › Article › peer-review

203 Scopus citations

Abstract

Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial brain tumors, in contrast, are therapy sensitive. Using magnetic resonance imaging (MRI) and detailed developmental analyses, we demonstrated that murine oligodendroglioma cells show characteristics of oligodendrocyte progenitor cells (OPCs) and are therapy sensitive, and that OPC rather than NSC markers enriched for tumor formation. MRI of human oligodendroglioma also suggested a white matter (WM) origin, with markers for OPCs rather than NSCs similarly enriching for tumor formation. Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor.

Original language	English
Pages (from-to)	669-682
Number of pages	14
Journal	Cancer Cell
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/j.ccr.2010.10.033
State	Published - Dec 14 2010

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10.1016/j.ccr.2010.10.033

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Persson, A. I., Petritsch, C., Swartling, F. J., Itsara, M., Sim, F. J., Auvergne, R., Goldenberg, D. D., Vandenberg, S. R., Nguyen, K. N., Yakovenko, S., Ayers-Ringler, J., Nishiyama, A., Stallcup, W. B., Berger, M. S., Bergers, G., McKnight, T. R., Goldman, S. A., & Weiss, W. A. (2010). Non-Stem Cell Origin for Oligodendroglioma. Cancer Cell, 18(6), 669-682. https://doi.org/10.1016/j.ccr.2010.10.033

@article{55d5ea81109a48f98eb22274858efe04,

title = "Non-Stem Cell Origin for Oligodendroglioma",

abstract = "Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial brain tumors, in contrast, are therapy sensitive. Using magnetic resonance imaging (MRI) and detailed developmental analyses, we demonstrated that murine oligodendroglioma cells show characteristics of oligodendrocyte progenitor cells (OPCs) and are therapy sensitive, and that OPC rather than NSC markers enriched for tumor formation. MRI of human oligodendroglioma also suggested a white matter (WM) origin, with markers for OPCs rather than NSCs similarly enriching for tumor formation. Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor.",

author = "Persson, \{Anders I.\} and Claudia Petritsch and Swartling, \{Fredrik J.\} and Melissa Itsara and Sim, \{Fraser J.\} and Romane Auvergne and Goldenberg, \{David D.\} and Vandenberg, \{Scott R.\} and Nguyen, \{Kim N.\} and Stanislava Yakovenko and Jennifer Ayers-Ringler and Akiko Nishiyama and Stallcup, \{William B.\} and Berger, \{Mitchel S.\} and Gabriele Bergers and McKnight, \{Tracy R.\} and Goldman, \{Steven A.\} and Weiss, \{William A.\}",

year = "2010",

month = dec,

day = "14",

doi = "10.1016/j.ccr.2010.10.033",

language = "English",

volume = "18",

pages = "669--682",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "6",

}

Persson, AI, Petritsch, C, Swartling, FJ, Itsara, M, Sim, FJ, Auvergne, R, Goldenberg, DD, Vandenberg, SR, Nguyen, KN, Yakovenko, S, Ayers-Ringler, J, Nishiyama, A, Stallcup, WB, Berger, MS, Bergers, G, McKnight, TR, Goldman, SA & Weiss, WA 2010, 'Non-Stem Cell Origin for Oligodendroglioma', Cancer Cell, vol. 18, no. 6, pp. 669-682. https://doi.org/10.1016/j.ccr.2010.10.033

TY - JOUR

T1 - Non-Stem Cell Origin for Oligodendroglioma

AU - Persson, Anders I.

AU - Petritsch, Claudia

AU - Swartling, Fredrik J.

AU - Itsara, Melissa

AU - Sim, Fraser J.

AU - Auvergne, Romane

AU - Goldenberg, David D.

AU - Vandenberg, Scott R.

AU - Nguyen, Kim N.

AU - Yakovenko, Stanislava

AU - Ayers-Ringler, Jennifer

AU - Nishiyama, Akiko

AU - Stallcup, William B.

AU - Berger, Mitchel S.

AU - Bergers, Gabriele

AU - McKnight, Tracy R.

AU - Goldman, Steven A.

AU - Weiss, William A.

PY - 2010/12/14

Y1 - 2010/12/14

N2 - Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial brain tumors, in contrast, are therapy sensitive. Using magnetic resonance imaging (MRI) and detailed developmental analyses, we demonstrated that murine oligodendroglioma cells show characteristics of oligodendrocyte progenitor cells (OPCs) and are therapy sensitive, and that OPC rather than NSC markers enriched for tumor formation. MRI of human oligodendroglioma also suggested a white matter (WM) origin, with markers for OPCs rather than NSCs similarly enriching for tumor formation. Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor.

AB - Malignant astrocytic brain tumors are among the most lethal cancers. Quiescent and therapy-resistant neural stem cell (NSC)-like cells in astrocytomas are likely to contribute to poor outcome. Malignant oligodendroglial brain tumors, in contrast, are therapy sensitive. Using magnetic resonance imaging (MRI) and detailed developmental analyses, we demonstrated that murine oligodendroglioma cells show characteristics of oligodendrocyte progenitor cells (OPCs) and are therapy sensitive, and that OPC rather than NSC markers enriched for tumor formation. MRI of human oligodendroglioma also suggested a white matter (WM) origin, with markers for OPCs rather than NSCs similarly enriching for tumor formation. Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor.

UR - https://www.scopus.com/pages/publications/78650002007

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DO - 10.1016/j.ccr.2010.10.033

M3 - Article

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AN - SCOPUS:78650002007

SN - 1535-6108

VL - 18

SP - 669

EP - 682

JO - Cancer Cell

JF - Cancer Cell

IS - 6

ER -

Non-Stem Cell Origin for Oligodendroglioma

Abstract

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