Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice

Susan Benloucif; Monica I. Masana; Phyllis C. Zee; Margarita L. Dubocovich

doi:10.1016/S0006-8993(02)04195-1

Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice

Susan Benloucif
, Monica I. Masana
, Phyllis C. Zee
, Margarita L. Dubocovich

Pharmacology and Toxicology

Northwestern University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The present study assessed whether treatment with the L-type calcium channel antagonist nimodipine affects the responsiveness of the circadian pacemaker to light in C3H/HeN mice. Nimodipine (10 mg/kg, sc) increased the magnitude of light-induced phase delays (P<0.01) and c-fos mRNA expression in the paraventricular nuclei (P<0.01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c-fos expression in the SCN.

Original language	English
Pages (from-to)	157-161
Number of pages	5
Journal	Brain Research
Volume	966
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(02)04195-1
State	Published - Mar 14 2003

Keywords

Calcium
Calcium antagonist
Immediate early gene
Phase delay

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10.1016/S0006-8993(02)04195-1

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title = "Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice",

abstract = "The present study assessed whether treatment with the L-type calcium channel antagonist nimodipine affects the responsiveness of the circadian pacemaker to light in C3H/HeN mice. Nimodipine (10 mg/kg, sc) increased the magnitude of light-induced phase delays (P<0.01) and c-fos mRNA expression in the paraventricular nuclei (P<0.01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c-fos expression in the SCN.",

keywords = "Calcium, Calcium antagonist, Immediate early gene, Phase delay",

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T1 - Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice

AU - Benloucif, Susan

AU - Masana, Monica I.

AU - Zee, Phyllis C.

AU - Dubocovich, Margarita L.

PY - 2003/3/14

Y1 - 2003/3/14

N2 - The present study assessed whether treatment with the L-type calcium channel antagonist nimodipine affects the responsiveness of the circadian pacemaker to light in C3H/HeN mice. Nimodipine (10 mg/kg, sc) increased the magnitude of light-induced phase delays (P<0.01) and c-fos mRNA expression in the paraventricular nuclei (P<0.01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c-fos expression in the SCN.

AB - The present study assessed whether treatment with the L-type calcium channel antagonist nimodipine affects the responsiveness of the circadian pacemaker to light in C3H/HeN mice. Nimodipine (10 mg/kg, sc) increased the magnitude of light-induced phase delays (P<0.01) and c-fos mRNA expression in the paraventricular nuclei (P<0.01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c-fos expression in the SCN.

KW - Calcium

KW - Calcium antagonist

KW - Immediate early gene

KW - Phase delay

UR - https://www.scopus.com/pages/publications/0037436470

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AN - SCOPUS:0037436470

SN - 0006-8993

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EP - 161

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice

Abstract

Keywords

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