New Syntheses of benzoporphyrin derivatives and analogues for use in photodynamic therapy

Isabelle Meunier; Ravindra K. Pandey; Michelle M. Walker; Mathias O. Senge; Thomas J. Dougherty; Kevin M. Smith

doi:10.1016/S0960-894X(00)80433-3

New Syntheses of benzoporphyrin derivatives and analogues for use in photodynamic therapy

Isabelle Meunier
, Ravindra K. Pandey
, Michelle M. Walker
, Mathias O. Senge
, Thomas J. Dougherty
, Kevin M. Smith

Institute for Lasers Photonics and Biophotonics

University of California at Davis
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

An efficient route for the synthesis of isomerically pure benzoporphyrin derivative (BPD) is presented. To understand more about structure/activity relationships in photodynamic therapy, a series of BPD derivatives, including dimers linked with carbon-carbon bonds were also prepared. The structure of the most effective (ring A) BPD isomer (14) was confirmed by a single crystal X-ray study.

Original language	English
Pages (from-to)	1575-1580
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(00)80433-3
State	Published - Dec 1992

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title = "New Syntheses of benzoporphyrin derivatives and analogues for use in photodynamic therapy",

abstract = "An efficient route for the synthesis of isomerically pure benzoporphyrin derivative (BPD) is presented. To understand more about structure/activity relationships in photodynamic therapy, a series of BPD derivatives, including dimers linked with carbon-carbon bonds were also prepared. The structure of the most effective (ring A) BPD isomer (14) was confirmed by a single crystal X-ray study.",

author = "Isabelle Meunier and Pandey, \{Ravindra K.\} and Walker, \{Michelle M.\} and Senge, \{Mathias O.\} and Dougherty, \{Thomas J.\} and Smith, \{Kevin M.\}",

year = "1992",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - New Syntheses of benzoporphyrin derivatives and analogues for use in photodynamic therapy

AU - Meunier, Isabelle

AU - Pandey, Ravindra K.

AU - Walker, Michelle M.

AU - Senge, Mathias O.

AU - Dougherty, Thomas J.

AU - Smith, Kevin M.

PY - 1992/12

Y1 - 1992/12

N2 - An efficient route for the synthesis of isomerically pure benzoporphyrin derivative (BPD) is presented. To understand more about structure/activity relationships in photodynamic therapy, a series of BPD derivatives, including dimers linked with carbon-carbon bonds were also prepared. The structure of the most effective (ring A) BPD isomer (14) was confirmed by a single crystal X-ray study.

AB - An efficient route for the synthesis of isomerically pure benzoporphyrin derivative (BPD) is presented. To understand more about structure/activity relationships in photodynamic therapy, a series of BPD derivatives, including dimers linked with carbon-carbon bonds were also prepared. The structure of the most effective (ring A) BPD isomer (14) was confirmed by a single crystal X-ray study.

UR - https://www.scopus.com/pages/publications/0026688651

U2 - 10.1016/S0960-894X(00)80433-3

DO - 10.1016/S0960-894X(00)80433-3

M3 - Article

AN - SCOPUS:0026688651

SN - 0960-894X

VL - 2

SP - 1575

EP - 1580

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

New Syntheses of benzoporphyrin derivatives and analogues for use in photodynamic therapy

Abstract

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