New matrix material for potential use in "reversible" vasectomy. Preliminary animal biocompatibility studies

John C. Carroll; Steven D. Schwaitzberg; Angelo A. Ucci; Robert M. Schlesinger; Derek Lauritzen; Grannum R. Sant

doi:10.1016/0090-4295(93)90240-B

New matrix material for potential use in "reversible" vasectomy. Preliminary animal biocompatibility studies

John C. Carroll
, Steven D. Schwaitzberg
, Angelo A. Ucci
, Robert M. Schlesinger
, Derek Lauritzen
, Grannum R. Sant

Surgery

Lemuel Shattuck Hospital

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The biocompatibility of a new elastomeric-hydrogel matrix biomaterial for use as an intravasal occlusive device was assessed by inserting it into the vas deferens of dogs. The vas was removed and examined histologically after varying periods of time. The biomaterial resulted in total occlusion of the vas. Epithelial changes were limited to squamous metaplasia in areas adjacent to the implant. Changes in the subepithelium were minimal. This new material is biocompatible with the dog vas, and it has potential as an occlusive device for "reversible" vasectomy in men. Semen analysis studies are needed to assess the completeness and reversibility of the nasal occlusion achieved with this implant.

Original language	English
Pages (from-to)	34-37
Number of pages	4
Journal	Urology
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/0090-4295(93)90240-B
State	Published - Jan 1993

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10.1016/0090-4295(93)90240-B

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@article{a462a86bdce744069fe64f217ef0b498,

title = "New matrix material for potential use in {"}reversible{"} vasectomy. Preliminary animal biocompatibility studies",

abstract = "The biocompatibility of a new elastomeric-hydrogel matrix biomaterial for use as an intravasal occlusive device was assessed by inserting it into the vas deferens of dogs. The vas was removed and examined histologically after varying periods of time. The biomaterial resulted in total occlusion of the vas. Epithelial changes were limited to squamous metaplasia in areas adjacent to the implant. Changes in the subepithelium were minimal. This new material is biocompatible with the dog vas, and it has potential as an occlusive device for {"}reversible{"} vasectomy in men. Semen analysis studies are needed to assess the completeness and reversibility of the nasal occlusion achieved with this implant.",

author = "Carroll, \{John C.\} and Schwaitzberg, \{Steven D.\} and Ucci, \{Angelo A.\} and Schlesinger, \{Robert M.\} and Derek Lauritzen and Sant, \{Grannum R.\}",

year = "1993",

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doi = "10.1016/0090-4295(93)90240-B",

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T1 - New matrix material for potential use in "reversible" vasectomy. Preliminary animal biocompatibility studies

AU - Carroll, John C.

AU - Schwaitzberg, Steven D.

AU - Ucci, Angelo A.

AU - Schlesinger, Robert M.

AU - Lauritzen, Derek

AU - Sant, Grannum R.

PY - 1993/1

Y1 - 1993/1

N2 - The biocompatibility of a new elastomeric-hydrogel matrix biomaterial for use as an intravasal occlusive device was assessed by inserting it into the vas deferens of dogs. The vas was removed and examined histologically after varying periods of time. The biomaterial resulted in total occlusion of the vas. Epithelial changes were limited to squamous metaplasia in areas adjacent to the implant. Changes in the subepithelium were minimal. This new material is biocompatible with the dog vas, and it has potential as an occlusive device for "reversible" vasectomy in men. Semen analysis studies are needed to assess the completeness and reversibility of the nasal occlusion achieved with this implant.

AB - The biocompatibility of a new elastomeric-hydrogel matrix biomaterial for use as an intravasal occlusive device was assessed by inserting it into the vas deferens of dogs. The vas was removed and examined histologically after varying periods of time. The biomaterial resulted in total occlusion of the vas. Epithelial changes were limited to squamous metaplasia in areas adjacent to the implant. Changes in the subepithelium were minimal. This new material is biocompatible with the dog vas, and it has potential as an occlusive device for "reversible" vasectomy in men. Semen analysis studies are needed to assess the completeness and reversibility of the nasal occlusion achieved with this implant.

UR - https://www.scopus.com/pages/publications/0027531085

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DO - 10.1016/0090-4295(93)90240-B

M3 - Article

C2 - 8420076

AN - SCOPUS:0027531085

SN - 0090-4295

VL - 41

SP - 34

EP - 37

JO - Urology

JF - Urology

IS - 1

ER -

New matrix material for potential use in "reversible" vasectomy. Preliminary animal biocompatibility studies

Abstract

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