Neurobiology of ADHD: A Review

Tejas R. Mehta; Alberto Monegro; Yash Nene; Muniba Fayyaz; Pradeep C. Bollu

doi:10.1007/s40474-019-00182-w

Neurobiology of ADHD: A Review

Tejas R. Mehta
, Alberto Monegro
, Yash Nene
, Muniba Fayyaz
, Pradeep C. Bollu

Medicine

University of Missouri

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Abstract

Purpose of Review: ADHD is a complex neuropsychiatric condition which has been known to cause a lot of changes in the structural and functional aspects as well as neurochemistry of the brain. Recent Findings: The structural aspects include changes primarily affecting but not limited to the prefrontal cortex, corpus striatum, and cerebellum. Dopamine and norepinephrine are the key neurotransmitters that are implicated in the pathophysiology of this condition. The above-mentioned neurotransmitter transporters and alterations or mutations to their genes have also been known to be a common finding in patients with ADHD. Summary: This review article summarizes the intertwined relationship between different parts of the brain in patients with ADHD along with neurochemical and genetic basis of this disease. Larger studies should be conducted to have a better and definitive understanding of the pathophysiology of the disease.

Original language	English
Pages (from-to)	235-240
Number of pages	6
Journal	Current Developmental Disorders Reports
Volume	6
Issue number	4
DOIs	https://doi.org/10.1007/s40474-019-00182-w
State	Published - Dec 1 2019

Keywords

ADHD
Neurobiological
Neurochemistry
Neurotransmitter
Structural

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10.1007/s40474-019-00182-w

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title = "Neurobiology of ADHD: A Review",

abstract = "Purpose of Review: ADHD is a complex neuropsychiatric condition which has been known to cause a lot of changes in the structural and functional aspects as well as neurochemistry of the brain. Recent Findings: The structural aspects include changes primarily affecting but not limited to the prefrontal cortex, corpus striatum, and cerebellum. Dopamine and norepinephrine are the key neurotransmitters that are implicated in the pathophysiology of this condition. The above-mentioned neurotransmitter transporters and alterations or mutations to their genes have also been known to be a common finding in patients with ADHD. Summary: This review article summarizes the intertwined relationship between different parts of the brain in patients with ADHD along with neurochemical and genetic basis of this disease. Larger studies should be conducted to have a better and definitive understanding of the pathophysiology of the disease.",

keywords = "ADHD, Neurobiological, Neurochemistry, Neurotransmitter, Structural",

author = "Mehta, \{Tejas R.\} and Alberto Monegro and Yash Nene and Muniba Fayyaz and Bollu, \{Pradeep C.\}",

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doi = "10.1007/s40474-019-00182-w",

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T2 - A Review

AU - Mehta, Tejas R.

AU - Monegro, Alberto

AU - Nene, Yash

AU - Fayyaz, Muniba

AU - Bollu, Pradeep C.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Purpose of Review: ADHD is a complex neuropsychiatric condition which has been known to cause a lot of changes in the structural and functional aspects as well as neurochemistry of the brain. Recent Findings: The structural aspects include changes primarily affecting but not limited to the prefrontal cortex, corpus striatum, and cerebellum. Dopamine and norepinephrine are the key neurotransmitters that are implicated in the pathophysiology of this condition. The above-mentioned neurotransmitter transporters and alterations or mutations to their genes have also been known to be a common finding in patients with ADHD. Summary: This review article summarizes the intertwined relationship between different parts of the brain in patients with ADHD along with neurochemical and genetic basis of this disease. Larger studies should be conducted to have a better and definitive understanding of the pathophysiology of the disease.

AB - Purpose of Review: ADHD is a complex neuropsychiatric condition which has been known to cause a lot of changes in the structural and functional aspects as well as neurochemistry of the brain. Recent Findings: The structural aspects include changes primarily affecting but not limited to the prefrontal cortex, corpus striatum, and cerebellum. Dopamine and norepinephrine are the key neurotransmitters that are implicated in the pathophysiology of this condition. The above-mentioned neurotransmitter transporters and alterations or mutations to their genes have also been known to be a common finding in patients with ADHD. Summary: This review article summarizes the intertwined relationship between different parts of the brain in patients with ADHD along with neurochemical and genetic basis of this disease. Larger studies should be conducted to have a better and definitive understanding of the pathophysiology of the disease.

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KW - Neurochemistry

KW - Neurotransmitter

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JO - Current Developmental Disorders Reports

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ER -

Neurobiology of ADHD: A Review

Abstract

Keywords

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