Nature: A rich source for developing multifunctional agents. Tumor-imaging and photodynamic therapy

Ravindra K. Pandey; Lalit N. Goswami; Yihui Chen; Amy Gryshuk; Joseph R. Missert; Allan Oseroff; Thomas J. Dougherty

doi:10.1002/lsm.20352

Nature: A rich source for developing multifunctional agents. Tumor-imaging and photodynamic therapy

Ravindra K. Pandey
, Lalit N. Goswami
, Yihui Chen
, Amy Gryshuk
, Joseph R. Missert
, Allan Oseroff
, Thomas J. Dougherty

Institute for Lasers Photonics and Biophotonics

Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

163 Scopus citations

Abstract

The purpose of this review is to call attention in the use of chlorophyll-a and bacteriochlorophyll-a to develop more than 600 photosensitizers (λ_max 660 nm-800 nm) during the last 15 years (1990-2005) at the Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo. This article mainly includes the chemistry, preclinical results, and brief clinical data of some of the most effective photosensitizers. The utility of the tumor-avid photosensitizers in developing multimodality agents (imaging and therapy) is also presented.

Original language	English
Pages (from-to)	445-467
Number of pages	23
Journal	Lasers in Surgery and Medicine
Volume	38
Issue number	5
DOIs	https://doi.org/10.1002/lsm.20352
State	Published - Jun 2006

Keywords

Age related macular degeneration
Fluorodeoxyglucose
MRI
PDT
PET

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10.1002/lsm.20352

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abstract = "The purpose of this review is to call attention in the use of chlorophyll-a and bacteriochlorophyll-a to develop more than 600 photosensitizers (λmax 660 nm-800 nm) during the last 15 years (1990-2005) at the Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo. This article mainly includes the chemistry, preclinical results, and brief clinical data of some of the most effective photosensitizers. The utility of the tumor-avid photosensitizers in developing multimodality agents (imaging and therapy) is also presented.",

keywords = "Age related macular degeneration, Fluorodeoxyglucose, MRI, PDT, PET",

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AU - Chen, Yihui

AU - Gryshuk, Amy

AU - Missert, Joseph R.

AU - Oseroff, Allan

AU - Dougherty, Thomas J.

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KW - Fluorodeoxyglucose

KW - MRI

KW - PDT

KW - PET

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Nature: A rich source for developing multifunctional agents. Tumor-imaging and photodynamic therapy

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Keywords

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