Natural rodent model of viral transmission reveals biological features of virus population dynamics

Elizabeth J. Fay; Keir M. Balla; Shanley N. Roach; Frances K. Shepherd; Dira S. Putri; Talia D. Wiggen; Stephen A. Goldstein; Mark J. Pierson; Martin T. Ferris; Claire E. Thefaine; Andrew Tucker; Mark Salnikov; Valerie Cortez; Susan R. Compton; Sergei V. Kotenko; Ryan C. Hunter; David Masopust; Nels C. Elde; Ryan A. Langlois

doi:10.1084/jem.20211220

Natural rodent model of viral transmission reveals biological features of virus population dynamics

Elizabeth J. Fay
, Keir M. Balla
, Shanley N. Roach
, Frances K. Shepherd
, Dira S. Putri
, Talia D. Wiggen
, Stephen A. Goldstein
, Mark J. Pierson
, Martin T. Ferris
, Claire E. Thefaine
, Andrew Tucker
, Mark Salnikov
, Valerie Cortez
, Susan R. Compton
, Sergei V. Kotenko
, Ryan C. Hunter
, David Masopust
, Nels C. Elde
, Ryan A. Langlois

Microbiology and Immunology

University of Minnesota Twin Cities
University of Utah
University of North Carolina at Chapel Hill
University of California at Santa Cruz
Yale University
Rutgers - The State University of New Jersey, New Brunswick

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Emerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- and cross-species transmission. Here, we leverage a model whereby pet store mice or rats-which harbor natural rodent pathogens-are cohoused with laboratory mice. This "dirty"mouse model offers a platform for studying acute transmission of viruses between and within hosts via natural mechanisms. We identified numerous viruses and other microbial species that transmit to cohoused mice, including prospective new members of the Coronaviridae, Astroviridae, Picornaviridae, and Narnaviridae families, and uncovered pathogen interactions that promote or prevent virus transmission. We also evaluated transmission dynamics ofmurine astroviruses during transmission and spread within a new host. Finally, by cohousing our laboratory mice with the bedding of pet store rats, we identified cross-species transmission of a rat astrovirus. Overall, this model system allows for the analysis of transmission of natural rodent viruses and is a platform to further characterize barriers to zoonosis.

Original language	English
Article number	e20211220
Journal	Journal of Experimental Medicine
Volume	219
Issue number	2
DOIs	https://doi.org/10.1084/jem.20211220
State	Published - Dec 27 2021

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10.1084/jem.20211220

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Fay, E. J., Balla, K. M., Roach, S. N., Shepherd, F. K., Putri, D. S., Wiggen, T. D., Goldstein, S. A., Pierson, M. J., Ferris, M. T., Thefaine, C. E., Tucker, A., Salnikov, M., Cortez, V., Compton, S. R., Kotenko, S. V., Hunter, R. C., Masopust, D., Elde, N. C., & Langlois, R. A. (2021). Natural rodent model of viral transmission reveals biological features of virus population dynamics. Journal of Experimental Medicine, 219(2), Article e20211220. https://doi.org/10.1084/jem.20211220

@article{4d2d77aeb58d43678d61ad4a3bbe587e,

title = "Natural rodent model of viral transmission reveals biological features of virus population dynamics",

abstract = "Emerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- and cross-species transmission. Here, we leverage a model whereby pet store mice or rats-which harbor natural rodent pathogens-are cohoused with laboratory mice. This {"}dirty{"}mouse model offers a platform for studying acute transmission of viruses between and within hosts via natural mechanisms. We identified numerous viruses and other microbial species that transmit to cohoused mice, including prospective new members of the Coronaviridae, Astroviridae, Picornaviridae, and Narnaviridae families, and uncovered pathogen interactions that promote or prevent virus transmission. We also evaluated transmission dynamics ofmurine astroviruses during transmission and spread within a new host. Finally, by cohousing our laboratory mice with the bedding of pet store rats, we identified cross-species transmission of a rat astrovirus. Overall, this model system allows for the analysis of transmission of natural rodent viruses and is a platform to further characterize barriers to zoonosis.",

author = "Fay, \{Elizabeth J.\} and Balla, \{Keir M.\} and Roach, \{Shanley N.\} and Shepherd, \{Frances K.\} and Putri, \{Dira S.\} and Wiggen, \{Talia D.\} and Goldstein, \{Stephen A.\} and Pierson, \{Mark J.\} and Ferris, \{Martin T.\} and Thefaine, \{Claire E.\} and Andrew Tucker and Mark Salnikov and Valerie Cortez and Compton, \{Susan R.\} and Kotenko, \{Sergei V.\} and Hunter, \{Ryan C.\} and David Masopust and Elde, \{Nels C.\} and Langlois, \{Ryan A.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Fay et al.",

year = "2021",

month = dec,

day = "27",

doi = "10.1084/jem.20211220",

language = "English",

volume = "219",

journal = "Journal of Experimental Medicine",

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Fay, EJ, Balla, KM, Roach, SN, Shepherd, FK, Putri, DS, Wiggen, TD, Goldstein, SA, Pierson, MJ, Ferris, MT, Thefaine, CE, Tucker, A, Salnikov, M, Cortez, V, Compton, SR, Kotenko, SV, Hunter, RC, Masopust, D, Elde, NC & Langlois, RA 2021, 'Natural rodent model of viral transmission reveals biological features of virus population dynamics', Journal of Experimental Medicine, vol. 219, no. 2, e20211220. https://doi.org/10.1084/jem.20211220

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T1 - Natural rodent model of viral transmission reveals biological features of virus population dynamics

AU - Fay, Elizabeth J.

AU - Balla, Keir M.

AU - Roach, Shanley N.

AU - Shepherd, Frances K.

AU - Putri, Dira S.

AU - Wiggen, Talia D.

AU - Goldstein, Stephen A.

AU - Pierson, Mark J.

AU - Ferris, Martin T.

AU - Thefaine, Claire E.

AU - Tucker, Andrew

AU - Salnikov, Mark

AU - Cortez, Valerie

AU - Compton, Susan R.

AU - Kotenko, Sergei V.

AU - Hunter, Ryan C.

AU - Masopust, David

AU - Elde, Nels C.

AU - Langlois, Ryan A.

PY - 2021/12/27

Y1 - 2021/12/27

N2 - Emerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- and cross-species transmission. Here, we leverage a model whereby pet store mice or rats-which harbor natural rodent pathogens-are cohoused with laboratory mice. This "dirty"mouse model offers a platform for studying acute transmission of viruses between and within hosts via natural mechanisms. We identified numerous viruses and other microbial species that transmit to cohoused mice, including prospective new members of the Coronaviridae, Astroviridae, Picornaviridae, and Narnaviridae families, and uncovered pathogen interactions that promote or prevent virus transmission. We also evaluated transmission dynamics ofmurine astroviruses during transmission and spread within a new host. Finally, by cohousing our laboratory mice with the bedding of pet store rats, we identified cross-species transmission of a rat astrovirus. Overall, this model system allows for the analysis of transmission of natural rodent viruses and is a platform to further characterize barriers to zoonosis.

AB - Emerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- and cross-species transmission. Here, we leverage a model whereby pet store mice or rats-which harbor natural rodent pathogens-are cohoused with laboratory mice. This "dirty"mouse model offers a platform for studying acute transmission of viruses between and within hosts via natural mechanisms. We identified numerous viruses and other microbial species that transmit to cohoused mice, including prospective new members of the Coronaviridae, Astroviridae, Picornaviridae, and Narnaviridae families, and uncovered pathogen interactions that promote or prevent virus transmission. We also evaluated transmission dynamics ofmurine astroviruses during transmission and spread within a new host. Finally, by cohousing our laboratory mice with the bedding of pet store rats, we identified cross-species transmission of a rat astrovirus. Overall, this model system allows for the analysis of transmission of natural rodent viruses and is a platform to further characterize barriers to zoonosis.

UR - https://www.scopus.com/pages/publications/85122706455

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DO - 10.1084/jem.20211220

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AN - SCOPUS:85122706455

SN - 0022-1007

VL - 219

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

IS - 2

M1 - e20211220

ER -

Natural rodent model of viral transmission reveals biological features of virus population dynamics

Abstract

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