Nasopharyngeal colonization by nontypeable Hemophilus influenzae in children: The effect of serum bactericidal antibody

J. M. Bernstein; H. S. Faden; P. L. Ogra

doi:10.1177/019459989110500309

Nasopharyngeal colonization by nontypeable Hemophilus influenzae in children: The effect of serum bactericidal antibody

J. M. Bernstein
, H. S. Faden
, P. L. Ogra

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The effect of serum bactericidal antibody on colonization with NTHI was studied in 26 children. Serum bactericidal antibody did not prevent colonization with NTHI in the nasopharynx. Antibody was detected in 53% before, 91% during, and 100% after documented colonization. The log titer of antibody was significantly higher during (1.18 ± 0.56), p < 0.002; and after (1.31 ± 0.29), p > 0.001 compared to before colonization (0.49 ± 0.51). The roles of secretory IgA and normal nasopharyngeal flora in inhibiting pathogenic bacteria are discussed.

Original language	English
Pages (from-to)	406-410
Number of pages	5
Journal	Otolaryngology - Head and Neck Surgery
Volume	105
Issue number	3
DOIs	https://doi.org/10.1177/019459989110500309
State	Published - 1991

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title = "Nasopharyngeal colonization by nontypeable Hemophilus influenzae in children: The effect of serum bactericidal antibody",

abstract = "The effect of serum bactericidal antibody on colonization with NTHI was studied in 26 children. Serum bactericidal antibody did not prevent colonization with NTHI in the nasopharynx. Antibody was detected in 53\% before, 91\% during, and 100\% after documented colonization. The log titer of antibody was significantly higher during (1.18 ± 0.56), p < 0.002; and after (1.31 ± 0.29), p > 0.001 compared to before colonization (0.49 ± 0.51). The roles of secretory IgA and normal nasopharyngeal flora in inhibiting pathogenic bacteria are discussed.",

author = "Bernstein, \{J. M.\} and Faden, \{H. S.\} and Ogra, \{P. L.\}",

year = "1991",

doi = "10.1177/019459989110500309",

language = "English",

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pages = "406--410",

journal = "Otolaryngology - Head and Neck Surgery",

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T1 - Nasopharyngeal colonization by nontypeable Hemophilus influenzae in children

T2 - The effect of serum bactericidal antibody

AU - Bernstein, J. M.

AU - Faden, H. S.

AU - Ogra, P. L.

PY - 1991

Y1 - 1991

N2 - The effect of serum bactericidal antibody on colonization with NTHI was studied in 26 children. Serum bactericidal antibody did not prevent colonization with NTHI in the nasopharynx. Antibody was detected in 53% before, 91% during, and 100% after documented colonization. The log titer of antibody was significantly higher during (1.18 ± 0.56), p < 0.002; and after (1.31 ± 0.29), p > 0.001 compared to before colonization (0.49 ± 0.51). The roles of secretory IgA and normal nasopharyngeal flora in inhibiting pathogenic bacteria are discussed.

AB - The effect of serum bactericidal antibody on colonization with NTHI was studied in 26 children. Serum bactericidal antibody did not prevent colonization with NTHI in the nasopharynx. Antibody was detected in 53% before, 91% during, and 100% after documented colonization. The log titer of antibody was significantly higher during (1.18 ± 0.56), p < 0.002; and after (1.31 ± 0.29), p > 0.001 compared to before colonization (0.49 ± 0.51). The roles of secretory IgA and normal nasopharyngeal flora in inhibiting pathogenic bacteria are discussed.

UR - https://www.scopus.com/pages/publications/0025719580

U2 - 10.1177/019459989110500309

DO - 10.1177/019459989110500309

M3 - Article

C2 - 1945426

AN - SCOPUS:0025719580

SN - 0194-5998

VL - 105

SP - 406

EP - 410

JO - Otolaryngology - Head and Neck Surgery

JF - Otolaryngology - Head and Neck Surgery

IS - 3

ER -

Nasopharyngeal colonization by nontypeable Hemophilus influenzae in children: The effect of serum bactericidal antibody

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