Nanobowl-Supported Liposomes Improve Drug Loading and Delivery

Zhong Jian Chen; Si Cong Yang; Xue Liang Liu; Yuhao Gao; Xiao Dong; Xing Lai; Mao Hua Zhu; Hai Yi Feng; Xin Di Zhu; Qin Lu; Mei Zhao; Hong Zhuan Chen; Jonathan F. Lovell; Chao Fang

doi:10.1021/acs.nanolett.0c00495

Nanobowl-Supported Liposomes Improve Drug Loading and Delivery

Zhong Jian Chen
, Si Cong Yang
, Xue Liang Liu
, Yuhao Gao
, Xiao Dong
, Xing Lai
, Mao Hua Zhu
, Hai Yi Feng
, Xin Di Zhu
, Qin Lu
, Mei Zhao
, Hong Zhuan Chen
, Jonathan F. Lovell
, Chao Fang

Department of Biomedical Engineering

Shanghai Jiao Tong University
Shanghai University of Medicine and Health Sciences
Shanghai University of Traditional Chinese Medicine

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery.

Original language	English
Pages (from-to)	4177-4187
Number of pages	11
Journal	Nano Letters
Volume	20
Issue number	6
DOIs	https://doi.org/10.1021/acs.nanolett.0c00495
State	Published - Jun 10 2020

Keywords

cancer therapy
doxorubicin
drug delivery
liposomes
Nanobowl

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10.1021/acs.nanolett.0c00495

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title = "Nanobowl-Supported Liposomes Improve Drug Loading and Delivery",

abstract = "Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery.",

keywords = "cancer therapy, doxorubicin, drug delivery, liposomes, Nanobowl",

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doi = "10.1021/acs.nanolett.0c00495",

language = "English",

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TY - JOUR

T1 - Nanobowl-Supported Liposomes Improve Drug Loading and Delivery

AU - Chen, Zhong Jian

AU - Yang, Si Cong

AU - Liu, Xue Liang

AU - Gao, Yuhao

AU - Dong, Xiao

AU - Lai, Xing

AU - Zhu, Mao Hua

AU - Feng, Hai Yi

AU - Zhu, Xin Di

AU - Lu, Qin

AU - Zhao, Mei

AU - Chen, Hong Zhuan

AU - Lovell, Jonathan F.

AU - Fang, Chao

PY - 2020/6/10

Y1 - 2020/6/10

N2 - Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery.

AB - Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. This approach yields improved drug delivery to tumor sites and enhanced antitumor efficacy. Compared to alternative methods of modifying liposome surface and composition for stability, this approach designs a physical support for an all-aqueous nanoliposomal cavity. Nanobowl stabilization of liposomes is a simple and effective method to improve carrier stability and drug delivery.

KW - cancer therapy

KW - doxorubicin

KW - drug delivery

KW - liposomes

KW - Nanobowl

UR - https://www.scopus.com/pages/publications/85085765232

U2 - 10.1021/acs.nanolett.0c00495

DO - 10.1021/acs.nanolett.0c00495

M3 - Article

C2 - 32431154

AN - SCOPUS:85085765232

SN - 1530-6984

VL - 20

SP - 4177

EP - 4187

JO - Nano Letters

JF - Nano Letters

IS - 6

ER -

Nanobowl-Supported Liposomes Improve Drug Loading and Delivery

Abstract

Keywords

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