Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium

Bianca Weinstock-Guttman; L. D. Jacobs; C. M. Brownscheidle; M. Baier; D. F. Rea; B. R. Apatoff; K. M. Blitz; P. K. Coyle; A. T. Frontera; A. D. Goodman; M. H. Gottesman; J. Herbert; R. Holub; N. S. Lava; M. Lenihan; J. Lusins; C. Mihai; A. E. Miller; A. B. Perel; D. H. Snyder; R. Bakshi; C. V. Granger; S. J. Greenberg; B. Jubelt; L. Krupp; F. E. Munschauer; D. Rubin; S. Schwid; J. Smiroldo; Sharon Cillis; Paul Walter; Linda Morgante; Timothy Galey; Eileen M. Gallagher; Lydia A. Green; Kathleen M. Hovey; Theresa A. Justinger; Colleen E. Miller; Michael R. Nazareth; Kara Patrick; Margaret Planter; David Smith; Margaret A. Umhauer; Rita L. Mammano; Kimberly Galante; Sharon Friedman-Urevich; Carrie Orapelo; Lisa Capolino; Lorene Wozniak; Mary Petrie; Mary Lou Pollock; Eileen Scheid; Illene Katkin; Wendy Ingoglia; Julie Carpenter; Leanne Waterman; Carol M. Brownscheidle

doi:10.1191/1352458503ms909oa

Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium

Bianca Weinstock-Guttman
, L. D. Jacobs
, C. M. Brownscheidle
, M. Baier
, D. F. Rea
, B. R. Apatoff
, K. M. Blitz
, P. K. Coyle
, A. T. Frontera
, A. D. Goodman
, M. H. Gottesman
, J. Herbert
, R. Holub
, N. S. Lava
, M. Lenihan
, J. Lusins
, C. Mihai
, A. E. Miller
, A. B. Perel
, D. H. Snyder

R. Bakshi, C. V. Granger, S. J. Greenberg, B. Jubelt, L. Krupp, F. E. Munschauer, D. Rubin, S. Schwid, J. Smiroldo, Sharon Cillis, Paul Walter, Linda Morgante, Timothy Galey, Eileen M. Gallagher, Lydia A. Green, Kathleen M. Hovey, Theresa A. Justinger, Colleen E. Miller, Michael R. Nazareth, Kara Patrick, Margaret Planter, David Smith, Margaret A. Umhauer, Rita L. Mammano, Kimberly Galante, Sharon Friedman-Urevich, Carrie Orapelo, Lisa Capolino, Lorene Wozniak, Mary Petrie, Mary Lou Pollock, Eileen Scheid, Illene Katkin, Wendy Ingoglia, Julie Carpenter, Leanne Waterman, Carol M. Brownscheidle

Neurology

SUNY Buffalo
University of Colorado Anschutz Medical Campus
New York Presbyterian Hospital
Northwell Health System
Stony Brook University
Kingston Neurological Associates
University of Rochester
Winthrop University Hospital
New York University
Neurological Associates of Albany
Albany Medical College
Glens Falls Neurology
Catskill Neurosci./Radiol. Assoc.
SUNY Upstate Medical University
Maimonides Medical Center

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Abstract

The objective of this study was to determine the clinical characteristics of multiple sclerosis (MS) in African American (AA) patients in the New York State Multiple Sclerosis Consortium (NYSMSC) patient registry. The NYSMSC is a group of 18 MS centers throughout New York State organized to prospectively assess clinical characteristics of MS patients. AAs comprise 6% (329) of the total NYSMSC registrants (5602). Demographics, disease course, therapy, and socioeconomic status were compared in AA registrants versus nonAfrican Americans (NAA). There was an increased female preponderance and a significantly younger age at diagnosis in the AA group. AA patients were more likely to have greater disability with increased disease duration. No differences were seen in types of MS and use of disease modifying therapies. Our findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility.

Original language	English
Pages (from-to)	293-298
Number of pages	6
Journal	Multiple Sclerosis
Volume	9
Issue number	3
DOIs	https://doi.org/10.1191/1352458503ms909oa
State	Published - Jun 2003

Keywords

African Americans
Autoimmune disease
Demyelinating disease
Epidemiology
Genetics
Multiple sclerosis
Neurodegenerative disease

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10.1191/1352458503ms909oa

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Weinstock-Guttman, B., Jacobs, L. D., Brownscheidle, C. M., Baier, M., Rea, D. F., Apatoff, B. R., Blitz, K. M., Coyle, P. K., Frontera, A. T., Goodman, A. D., Gottesman, M. H., Herbert, J., Holub, R., Lava, N. S., Lenihan, M., Lusins, J., Mihai, C., Miller, A. E., Perel, A. B., ... Brownscheidle, C. M. (2003). Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium. Multiple Sclerosis, 9(3), 293-298. https://doi.org/10.1191/1352458503ms909oa

@article{9c9f020c767d4a5f997bdc9fb6b36ef9,

title = "Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium",

abstract = "The objective of this study was to determine the clinical characteristics of multiple sclerosis (MS) in African American (AA) patients in the New York State Multiple Sclerosis Consortium (NYSMSC) patient registry. The NYSMSC is a group of 18 MS centers throughout New York State organized to prospectively assess clinical characteristics of MS patients. AAs comprise 6\% (329) of the total NYSMSC registrants (5602). Demographics, disease course, therapy, and socioeconomic status were compared in AA registrants versus nonAfrican Americans (NAA). There was an increased female preponderance and a significantly younger age at diagnosis in the AA group. AA patients were more likely to have greater disability with increased disease duration. No differences were seen in types of MS and use of disease modifying therapies. Our findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility.",

keywords = "African Americans, Autoimmune disease, Demyelinating disease, Epidemiology, Genetics, Multiple sclerosis, Neurodegenerative disease",

author = "Bianca Weinstock-Guttman and Jacobs, \{L. D.\} and Brownscheidle, \{C. M.\} and M. Baier and Rea, \{D. F.\} and Apatoff, \{B. R.\} and Blitz, \{K. M.\} and Coyle, \{P. K.\} and Frontera, \{A. T.\} and Goodman, \{A. D.\} and Gottesman, \{M. H.\} and J. Herbert and R. Holub and Lava, \{N. S.\} and M. Lenihan and J. Lusins and C. Mihai and Miller, \{A. E.\} and Perel, \{A. B.\} and Snyder, \{D. H.\} and R. Bakshi and Granger, \{C. V.\} and Greenberg, \{S. J.\} and B. Jubelt and L. Krupp and Munschauer, \{F. E.\} and D. Rubin and S. Schwid and J. Smiroldo and Sharon Cillis and Paul Walter and Linda Morgante and Timothy Galey and Gallagher, \{Eileen M.\} and Green, \{Lydia A.\} and Hovey, \{Kathleen M.\} and Justinger, \{Theresa A.\} and Miller, \{Colleen E.\} and Nazareth, \{Michael R.\} and Kara Patrick and Margaret Planter and David Smith and Umhauer, \{Margaret A.\} and Mammano, \{Rita L.\} and Kimberly Galante and Sharon Friedman-Urevich and Carrie Orapelo and Lisa Capolino and Lorene Wozniak and Mary Petrie and Pollock, \{Mary Lou\} and Eileen Scheid and Illene Katkin and Wendy Ingoglia and Julie Carpenter and Leanne Waterman and Brownscheidle, \{Carol M.\}",

year = "2003",

month = jun,

doi = "10.1191/1352458503ms909oa",

language = "English",

volume = "9",

pages = "293--298",

journal = "Multiple Sclerosis",

issn = "1352-4585",

publisher = "SAGE Publications Ltd",

number = "3",

}

Weinstock-Guttman, B, Jacobs, LD, Brownscheidle, CM, Baier, M, Rea, DF, Apatoff, BR, Blitz, KM, Coyle, PK, Frontera, AT, Goodman, AD, Gottesman, MH, Herbert, J, Holub, R, Lava, NS, Lenihan, M, Lusins, J, Mihai, C, Miller, AE, Perel, AB, Snyder, DH, Bakshi, R, Granger, CV, Greenberg, SJ, Jubelt, B, Krupp, L, Munschauer, FE, Rubin, D, Schwid, S, Smiroldo, J, Cillis, S, Walter, P, Morgante, L, Galey, T, Gallagher, EM, Green, LA, Hovey, KM, Justinger, TA, Miller, CE, Nazareth, MR, Patrick, K, Planter, M, Smith, D, Umhauer, MA, Mammano, RL, Galante, K, Friedman-Urevich, S, Orapelo, C, Capolino, L, Wozniak, L, Petrie, M, Pollock, ML, Scheid, E, Katkin, I, Ingoglia, W, Carpenter, J, Waterman, L & Brownscheidle, CM 2003, 'Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium', Multiple Sclerosis, vol. 9, no. 3, pp. 293-298. https://doi.org/10.1191/1352458503ms909oa

TY - JOUR

T1 - Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium

AU - Weinstock-Guttman, Bianca

AU - Jacobs, L. D.

AU - Brownscheidle, C. M.

AU - Baier, M.

AU - Rea, D. F.

AU - Apatoff, B. R.

AU - Blitz, K. M.

AU - Coyle, P. K.

AU - Frontera, A. T.

AU - Goodman, A. D.

AU - Gottesman, M. H.

AU - Herbert, J.

AU - Holub, R.

AU - Lava, N. S.

AU - Lenihan, M.

AU - Lusins, J.

AU - Mihai, C.

AU - Miller, A. E.

AU - Perel, A. B.

AU - Snyder, D. H.

AU - Bakshi, R.

AU - Granger, C. V.

AU - Greenberg, S. J.

AU - Jubelt, B.

AU - Krupp, L.

AU - Munschauer, F. E.

AU - Rubin, D.

AU - Schwid, S.

AU - Smiroldo, J.

AU - Cillis, Sharon

AU - Walter, Paul

AU - Morgante, Linda

AU - Galey, Timothy

AU - Gallagher, Eileen M.

AU - Green, Lydia A.

AU - Hovey, Kathleen M.

AU - Justinger, Theresa A.

AU - Miller, Colleen E.

AU - Nazareth, Michael R.

AU - Patrick, Kara

AU - Planter, Margaret

AU - Smith, David

AU - Umhauer, Margaret A.

AU - Mammano, Rita L.

AU - Galante, Kimberly

AU - Friedman-Urevich, Sharon

AU - Orapelo, Carrie

AU - Capolino, Lisa

AU - Wozniak, Lorene

AU - Petrie, Mary

AU - Pollock, Mary Lou

AU - Scheid, Eileen

AU - Katkin, Illene

AU - Ingoglia, Wendy

AU - Carpenter, Julie

AU - Waterman, Leanne

AU - Brownscheidle, Carol M.

PY - 2003/6

Y1 - 2003/6

N2 - The objective of this study was to determine the clinical characteristics of multiple sclerosis (MS) in African American (AA) patients in the New York State Multiple Sclerosis Consortium (NYSMSC) patient registry. The NYSMSC is a group of 18 MS centers throughout New York State organized to prospectively assess clinical characteristics of MS patients. AAs comprise 6% (329) of the total NYSMSC registrants (5602). Demographics, disease course, therapy, and socioeconomic status were compared in AA registrants versus nonAfrican Americans (NAA). There was an increased female preponderance and a significantly younger age at diagnosis in the AA group. AA patients were more likely to have greater disability with increased disease duration. No differences were seen in types of MS and use of disease modifying therapies. Our findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility.

AB - The objective of this study was to determine the clinical characteristics of multiple sclerosis (MS) in African American (AA) patients in the New York State Multiple Sclerosis Consortium (NYSMSC) patient registry. The NYSMSC is a group of 18 MS centers throughout New York State organized to prospectively assess clinical characteristics of MS patients. AAs comprise 6% (329) of the total NYSMSC registrants (5602). Demographics, disease course, therapy, and socioeconomic status were compared in AA registrants versus nonAfrican Americans (NAA). There was an increased female preponderance and a significantly younger age at diagnosis in the AA group. AA patients were more likely to have greater disability with increased disease duration. No differences were seen in types of MS and use of disease modifying therapies. Our findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility.

KW - African Americans

KW - Autoimmune disease

KW - Demyelinating disease

KW - Epidemiology

KW - Genetics

KW - Multiple sclerosis

KW - Neurodegenerative disease

UR - https://www.scopus.com/pages/publications/0038660098

U2 - 10.1191/1352458503ms909oa

DO - 10.1191/1352458503ms909oa

M3 - Article

C2 - 12814178

AN - SCOPUS:0038660098

SN - 1352-4585

VL - 9

SP - 293

EP - 298

JO - Multiple Sclerosis

JF - Multiple Sclerosis

IS - 3

ER -

Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium

Abstract

Keywords

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