Multiple roles for B-lymphocytes in sjogren’s syndrome

Julian Lawrence Ambrus; Lakshmanan Suresh; Ammon Peck

doi:10.3390/jcm5100087

Multiple roles for B-lymphocytes in sjogren’s syndrome

University of Florida

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Sjogren’s syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell-directed therapies in the management of patients with SS.

Original language	English
Article number	87
Journal	Journal of Clinical Medicine
Volume	5
Issue number	10
DOIs	https://doi.org/10.3390/jcm5100087
State	Published - Oct 1 2016

Keywords

B cells
Marginal zone B cells
Sjogren’s syndrome

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10.3390/jcm5100087

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title = "Multiple roles for B-lymphocytes in sjogren{\textquoteright}s syndrome",

abstract = "Sjogren{\textquoteright}s syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell-directed therapies in the management of patients with SS.",

keywords = "B cells, Marginal zone B cells, Sjogren{\textquoteright}s syndrome",

author = "Ambrus, \{Julian Lawrence\} and Lakshmanan Suresh and Ammon Peck",

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AU - Ambrus, Julian Lawrence

AU - Suresh, Lakshmanan

AU - Peck, Ammon

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Sjogren’s syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell-directed therapies in the management of patients with SS.

AB - Sjogren’s syndrome (SS) is a complex heterogeneous autoimmune disease resulting in loss of salivary gland and lacrimal gland function that may include multiple systemic manifestations including lymphoma. Multiple cell types participate in disease pathogenesis. This review discusses evidence for abnormal B cell subpopulations in patients with SS, critical roles of B cells in SS and the status of B cell-directed therapies in the management of patients with SS.

KW - B cells

KW - Marginal zone B cells

KW - Sjogren’s syndrome

UR - https://www.scopus.com/pages/publications/85032153487

U2 - 10.3390/jcm5100087

DO - 10.3390/jcm5100087

M3 - Review article

AN - SCOPUS:85032153487

SN - 2077-0383

VL - 5

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 10

M1 - 87

ER -

Multiple roles for B-lymphocytes in sjogren’s syndrome

Abstract

Keywords

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