Morphine as a cue in associative tolerance to morphine's analgesic effects

Antonio Cepeda-Benito; Stephen T. Tiffany

doi:10.1016/0091-3057(93)90332-N

Morphine as a cue in associative tolerance to morphine's analgesic effects

Antonio Cepeda-Benito
, Stephen T. Tiffany

Psychology

Purdue University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This study examined the extent to which low doses of morphine paired explicity with high doses would gain associative control over tolerance development in rats. Tolerance development was assessed by evaluating dose-response curves to the analgesic effects of morphine on the tail-flick test. The results indicated that tolerance development was not influenced by the pairing of low doses with high doses.

Original language	English
Pages (from-to)	149-152
Number of pages	4
Journal	Pharmacology Biochemistry and Behavior
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(93)90332-N
State	Published - Sep 1993

Keywords

Conditioning
Dose-response curves
Interoceptive cues
Morphine
Tail-flick
Tolerence

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10.1016/0091-3057(93)90332-N

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title = "Morphine as a cue in associative tolerance to morphine's analgesic effects",

abstract = "This study examined the extent to which low doses of morphine paired explicity with high doses would gain associative control over tolerance development in rats. Tolerance development was assessed by evaluating dose-response curves to the analgesic effects of morphine on the tail-flick test. The results indicated that tolerance development was not influenced by the pairing of low doses with high doses.",

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AB - This study examined the extent to which low doses of morphine paired explicity with high doses would gain associative control over tolerance development in rats. Tolerance development was assessed by evaluating dose-response curves to the analgesic effects of morphine on the tail-flick test. The results indicated that tolerance development was not influenced by the pairing of low doses with high doses.

KW - Conditioning

KW - Dose-response curves

KW - Interoceptive cues

KW - Morphine

KW - Tail-flick

KW - Tolerence

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U2 - 10.1016/0091-3057(93)90332-N

DO - 10.1016/0091-3057(93)90332-N

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IS - 1

ER -

Morphine as a cue in associative tolerance to morphine's analgesic effects

Abstract

Keywords

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