Monoclonal antibodies to A3G7 protein associated with nervous tissue growth disturb learning and memory in adult rats

Effect of monoclonal antibodies to A3G7 protein specific for cerebellar Purkinje cells and hippocampal pyramidal neurons on learning, consolidation, and retrieval of short-and long-term habituation to acoustic startle reaction is studied in adult rats. Application of 1 mg/ml antibodies to the cerebellar vermis selectively disturbs long-term habituation, while 2 mg/ml antibodies inhibit both short- and long-term habituation. The data are analyzed with consideration of the involvement of A3G7 protein into nerve growth and neurotransmittory processes underlying learning and memory in developing and mature brain.