Abstract
An attempt was made to describe quantitatively the deviations from ideal solubility of nonelectrolytes in nonpolar solvents as a result of three contributions: (a) entropic, (b) regular solution, and (c) specific interactions. The relative magnitudes of these contributions were theoretically estimated. Experimentally, it was found that for the systems studied involving poorly soluble polar solutes in a series of hydrocarbon solvents, the entropic correction term appeared to account for deviation from ideal solubility behavior. Regular solution correction appeared to be unnecessary for these systems. Specific interactions were found to be the dominant factors in determining solubilities of polar solutes in solvents possessing acid–base characters. Solvate association constants between various solutes and chloroform or ether were determined by the solubility technique. The good agreement between solubility data and solvate equilibria equations for a wide variety of chemically different solutes and the two interacting solvents seems to indicate support for the stoichiometric solvate species treatment of solubility.
| Original language | English |
|---|---|
| Pages (from-to) | 1782-1788 |
| Number of pages | 7 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 60 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1971 |
Keywords
- Nonelectrolytes, polar, solubility in nonpolar solvents—consideration of entropic, enthalpic, and specific interactions
- Solubility, nonelectrolytes, polar—in nonpolar solvents, consideration of entropic–enthalpic–specific interactions
- Solvation—polar organic solvents, stoichiometric species approach
Fingerprint
Dive into the research topics of 'Molecular interactions and solubility of polar nonelectrolytes in nonpolar solvents'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver