Molecular conformation of prostaglandin E2

James W. Edmonds; William L. Duax

doi:10.1016/0090-6980(74)90056-2

Molecular conformation of prostaglandin E₂

James W. Edmonds
, William L. Duax

Department of Structural Biology

Hauptman-Woodward Medical Research Institute, Inc.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The crystal and molecular structure of prostaglandin E₂ (PGE₂) has been determined by X-ray diffraction. The compound crystallizes in the triclinic space group P1 with Z = 1 and a = 9.751 A ̊, b = 10.542 A ̊, c = 5.176 A ̊, α = 87.347°, β = 94.042°, and γ = 91.010°. Gauche-gauche interactions appear in both side chains. The efficient molecular packing and hydrogen bonding network appears to stabilize the observed molecular conformation.

Original language	English
Pages (from-to)	275-281
Number of pages	7
Journal	Prostaglandins
Volume	5
Issue number	3
DOIs	https://doi.org/10.1016/0090-6980(74)90056-2
State	Published - Feb 10 1974

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title = "Molecular conformation of prostaglandin E2",

abstract = "The crystal and molecular structure of prostaglandin E2 (PGE2) has been determined by X-ray diffraction. The compound crystallizes in the triclinic space group P1 with Z = 1 and a = 9.751 A ̊, b = 10.542 A ̊, c = 5.176 A ̊, α = 87.347°, β = 94.042°, and γ = 91.010°. Gauche-gauche interactions appear in both side chains. The efficient molecular packing and hydrogen bonding network appears to stabilize the observed molecular conformation.",

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T1 - Molecular conformation of prostaglandin E2

AU - Edmonds, James W.

AU - Duax, William L.

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N2 - The crystal and molecular structure of prostaglandin E2 (PGE2) has been determined by X-ray diffraction. The compound crystallizes in the triclinic space group P1 with Z = 1 and a = 9.751 A ̊, b = 10.542 A ̊, c = 5.176 A ̊, α = 87.347°, β = 94.042°, and γ = 91.010°. Gauche-gauche interactions appear in both side chains. The efficient molecular packing and hydrogen bonding network appears to stabilize the observed molecular conformation.

AB - The crystal and molecular structure of prostaglandin E2 (PGE2) has been determined by X-ray diffraction. The compound crystallizes in the triclinic space group P1 with Z = 1 and a = 9.751 A ̊, b = 10.542 A ̊, c = 5.176 A ̊, α = 87.347°, β = 94.042°, and γ = 91.010°. Gauche-gauche interactions appear in both side chains. The efficient molecular packing and hydrogen bonding network appears to stabilize the observed molecular conformation.

UR - https://www.scopus.com/pages/publications/0015980307

U2 - 10.1016/0090-6980(74)90056-2

DO - 10.1016/0090-6980(74)90056-2

M3 - Article

C2 - 4824818

AN - SCOPUS:0015980307

SN - 0090-6980

VL - 5

SP - 275

EP - 281

JO - Prostaglandins

JF - Prostaglandins

IS - 3

ER -

Molecular conformation of prostaglandin E₂

Abstract

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