Molecular autopsy provides evidence for widespread ribosome-phased mRNA fragmentation

Tatsuaki Kurosaki; Lynne E. Maquat

doi:10.1038/s41594-018-0048-2

Molecular autopsy provides evidence for widespread ribosome-phased mRNA fragmentation

Tatsuaki Kurosaki
, Lynne E. Maquat

Biotechnical and Clinical Laboratory Sciences

University of Rochester

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Recent developments in transcriptome-wide sequencing technologies have enabled the identification of cellular mRNA decay intermediates. Although canonical mRNA decay has been shown to occur by deadenylation followed by decapping and subsequent exonucleolytic decay from both mRNA ends, a study by Mourelatos and colleagues now defines mRNA fragments that are generated on polysomes by endonucleolytic cleavages phased by the associated ribosome.

Original language	English
Pages (from-to)	299-301
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	25
Issue number	4
DOIs	https://doi.org/10.1038/s41594-018-0048-2
State	Published - Apr 1 2018

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title = "Molecular autopsy provides evidence for widespread ribosome-phased mRNA fragmentation",

abstract = "Recent developments in transcriptome-wide sequencing technologies have enabled the identification of cellular mRNA decay intermediates. Although canonical mRNA decay has been shown to occur by deadenylation followed by decapping and subsequent exonucleolytic decay from both mRNA ends, a study by Mourelatos and colleagues now defines mRNA fragments that are generated on polysomes by endonucleolytic cleavages phased by the associated ribosome.",

author = "Tatsuaki Kurosaki and Maquat, \{Lynne E.\}",

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AU - Maquat, Lynne E.

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N2 - Recent developments in transcriptome-wide sequencing technologies have enabled the identification of cellular mRNA decay intermediates. Although canonical mRNA decay has been shown to occur by deadenylation followed by decapping and subsequent exonucleolytic decay from both mRNA ends, a study by Mourelatos and colleagues now defines mRNA fragments that are generated on polysomes by endonucleolytic cleavages phased by the associated ribosome.

AB - Recent developments in transcriptome-wide sequencing technologies have enabled the identification of cellular mRNA decay intermediates. Although canonical mRNA decay has been shown to occur by deadenylation followed by decapping and subsequent exonucleolytic decay from both mRNA ends, a study by Mourelatos and colleagues now defines mRNA fragments that are generated on polysomes by endonucleolytic cleavages phased by the associated ribosome.

UR - https://www.scopus.com/pages/publications/85044239477

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DO - 10.1038/s41594-018-0048-2

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JO - Nature Structural and Molecular Biology

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Molecular autopsy provides evidence for widespread ribosome-phased mRNA fragmentation

Abstract

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