Modified synthesis and antiangiogenic activity of Linomide

Saeed R. Khan; Annastasiah Mhaka; Roberto Pili; John T. Isaacs

doi:10.1016/S0960-894X(00)00699-5

Modified synthesis and antiangiogenic activity of Linomide

Saeed R. Khan
, Annastasiah Mhaka
, Roberto Pili
, John T. Isaacs

Medicine

Johns Hopkins University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.

Original language	English
Pages (from-to)	451-452
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/S0960-894X(00)00699-5
State	Published - Feb 26 2001

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title = "Modified synthesis and antiangiogenic activity of Linomide",

abstract = "A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.",

author = "Khan, \{Saeed R.\} and Annastasiah Mhaka and Roberto Pili and Isaacs, \{John T.\}",

year = "2001",

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T1 - Modified synthesis and antiangiogenic activity of Linomide

AU - Khan, Saeed R.

AU - Mhaka, Annastasiah

AU - Pili, Roberto

AU - Isaacs, John T.

PY - 2001/2/26

Y1 - 2001/2/26

N2 - A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.

AB - A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.

UR - https://www.scopus.com/pages/publications/0035952256

U2 - 10.1016/S0960-894X(00)00699-5

DO - 10.1016/S0960-894X(00)00699-5

M3 - Article

C2 - 11229745

AN - SCOPUS:0035952256

SN - 0960-894X

VL - 11

SP - 451

EP - 452

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 4

ER -

Modified synthesis and antiangiogenic activity of Linomide

Abstract

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