TY - GEN
T1 - Modeling post-impact injury propagation in traumatic brain injury
AU - Pillai, Nikhil
AU - Patra, Abani
AU - Esfahani, Ehsan
N1 - Publisher Copyright:
Copyright © 2016 by ASME.
PY - 2016
Y1 - 2016
N2 - In this paper, we investigate the effect of mechanical deformation during original impact on the propagation of bleeds during traumatic brain injury (TBI). For this purpose, we have developed a numerical framework that considers Magnetic Resonance Images (MRI) of a rat subjected to TBI modelled using controlled cortical impact (CCI). Using the MRI images of first day of impact a solid model of brain is developed and strains during impact are estimated using the finite element tool LSDyna. It was observed that the actual propagation of blood obtained from day 14 MRI data closely resembles the one developed by solving a time dependent advection equation with advection rates proportional to the strain estimates during impact from LSDyna. This numerical framework holds promise that with proper calibration and validation it can be used to predict the possible propagation of blood post-impact and therefore may be used to inform treatment protocols for such patients.
AB - In this paper, we investigate the effect of mechanical deformation during original impact on the propagation of bleeds during traumatic brain injury (TBI). For this purpose, we have developed a numerical framework that considers Magnetic Resonance Images (MRI) of a rat subjected to TBI modelled using controlled cortical impact (CCI). Using the MRI images of first day of impact a solid model of brain is developed and strains during impact are estimated using the finite element tool LSDyna. It was observed that the actual propagation of blood obtained from day 14 MRI data closely resembles the one developed by solving a time dependent advection equation with advection rates proportional to the strain estimates during impact from LSDyna. This numerical framework holds promise that with proper calibration and validation it can be used to predict the possible propagation of blood post-impact and therefore may be used to inform treatment protocols for such patients.
UR - https://www.scopus.com/pages/publications/85007363528
U2 - 10.1115/DETC2016-60444
DO - 10.1115/DETC2016-60444
M3 - Conference contribution
AN - SCOPUS:85007363528
T3 - Proceedings of the ASME Design Engineering Technical Conference
BT - 18th International Conference on Advanced Vehicle Technologies; 13th International Conference on Design Education; 9th Frontiers in Biomedical Devices
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 2016 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2016
Y2 - 21 August 2016 through 24 August 2016
ER -