@inproceedings{d8939e90a8d245928357faf3a42ed2ef,
title = "Modeling of glucose-insulin system dynamics in diabetic Goettingen minipigs",
abstract = "Development of an artificial pancreas which regulates blood glucose in a closed loop framework is the ultimate goal in the treatment of diabetes. Development of a model which captures the glucose-insulin dynamic is a mandatory step prior to the in vivo-test and validation of a feedback controller. Towards this end, the focus of this paper is on the development of a glucose-insulin model for diabetic Goettingen minipigs, which will serve as a proxy for human testing of a blood glucose regulator. This paper presents an eighth-order model to capture the glucose-insulin dynamics in diabetic Goettingen minipigs. Comparison of the measurement data with the calculated evolution of the blood glucose trajectories illustrates satisfactory results providing a basis of optimism for the ultimate implementation of a closed loop controller.",
keywords = "Compartment models, Diabetes type 1, Glucose-insulin system, Goettingen minipigs, Oral glucose tolerance test",
author = "Katrin Lunze and Tarunraj Singh and Steffen Leonhardt",
year = "2012",
doi = "10.3182/20120829-3-HU-2029.00018",
language = "English",
isbn = "9783902823106",
series = "IFAC Proceedings Volumes (IFAC-PapersOnline)",
publisher = "IFAC Secretariat",
number = "18",
pages = "414--419",
booktitle = "Proceedings of the 8th IFAC Symposium on Biological and Medical Systems, BMS 2012",
edition = "18",
note = "8th IFAC Symposium on Biological and Medical Systems, BMS 2012 ; Conference date: 29-08-2012 Through 31-08-2012",
}