Modeling of drug release from polymer matrix via diffusion and erosion

Suddha S. Talukdar; Yang Lin; Paschalis Alexandridis

Modeling of drug release from polymer matrix via diffusion and erosion

Suddha S. Talukdar
, Yang Lin
, Paschalis Alexandridis

Department of Chemical and Biological Engineering

SUNY Buffalo

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

A mathematical model capable of relating the diffusion of the solute molecules in a polymer tablet and the concurrent erosion of the polymer matrix resulting in solute release was developed to understand the release mechanism of solute molecules from polymer matrix. A new equation was developed for the boundary condition. Total solute release was quantified in terms of diffusion and erosion contributions. Results from the slab geometry reflect the results observed during the experimental analysis of drug release from Pluronic hydrogels.

Original language	English
Pages (from-to)	1659-1660
Number of pages	2
Journal	American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume	41
Issue number	2
State	Published - Aug 2000
Event	Washington,DC. Meeting - Washington, DC, USA Duration: Aug 20 2000 → Aug 24 2000

Cite this

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title = "Modeling of drug release from polymer matrix via diffusion and erosion",

abstract = "A mathematical model capable of relating the diffusion of the solute molecules in a polymer tablet and the concurrent erosion of the polymer matrix resulting in solute release was developed to understand the release mechanism of solute molecules from polymer matrix. A new equation was developed for the boundary condition. Total solute release was quantified in terms of diffusion and erosion contributions. Results from the slab geometry reflect the results observed during the experimental analysis of drug release from Pluronic hydrogels.",

author = "Talukdar, \{Suddha S.\} and Yang Lin and Paschalis Alexandridis",

year = "2000",

month = aug,

language = "English",

volume = "41",

pages = "1659--1660",

journal = "American Chemical Society, Polymer Preprints, Division of Polymer Chemistry",

issn = "0032-3934",

number = "2",

note = "Washington,DC. Meeting ; Conference date: 20-08-2000 Through 24-08-2000",

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TY - JOUR

T1 - Modeling of drug release from polymer matrix via diffusion and erosion

AU - Talukdar, Suddha S.

AU - Lin, Yang

AU - Alexandridis, Paschalis

PY - 2000/8

Y1 - 2000/8

N2 - A mathematical model capable of relating the diffusion of the solute molecules in a polymer tablet and the concurrent erosion of the polymer matrix resulting in solute release was developed to understand the release mechanism of solute molecules from polymer matrix. A new equation was developed for the boundary condition. Total solute release was quantified in terms of diffusion and erosion contributions. Results from the slab geometry reflect the results observed during the experimental analysis of drug release from Pluronic hydrogels.

AB - A mathematical model capable of relating the diffusion of the solute molecules in a polymer tablet and the concurrent erosion of the polymer matrix resulting in solute release was developed to understand the release mechanism of solute molecules from polymer matrix. A new equation was developed for the boundary condition. Total solute release was quantified in terms of diffusion and erosion contributions. Results from the slab geometry reflect the results observed during the experimental analysis of drug release from Pluronic hydrogels.

UR - https://www.scopus.com/pages/publications/0034249639

M3 - Conference article

AN - SCOPUS:0034249639

SN - 0032-3934

VL - 41

SP - 1659

EP - 1660

JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

IS - 2

T2 - Washington,DC. Meeting

Y2 - 20 August 2000 through 24 August 2000

ER -

Modeling of drug release from polymer matrix via diffusion and erosion

Abstract

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