TY - GEN
T1 - Microfluidic network based combinatorial device for high throughput screening and optimization
AU - Lee, Kangsun
AU - Kim, Choong
AU - Jung, Keunhui
AU - Kang, Ji Yoon
AU - Oh, Kwang W.
PY - 2009
Y1 - 2009
N2 - We present a combinatorial dilution device using a 3-layer microfluidic network that can produce systematic variations of all buffer and additive solutions in a combinatorial fashion for high throughput screening and optimization. A proof-of-concept device providing 7 combinations (ABC/D, AB/D, BC/D, AC/D, A/D, B/D, and C/D) of 3 additive samples (A, B, and C) into a buffer solution (D) has been demonstrated. Based on mathematical modeling and electrical and computational fluid dynamic simulations, the device has been designed, fabricated and characterized.
AB - We present a combinatorial dilution device using a 3-layer microfluidic network that can produce systematic variations of all buffer and additive solutions in a combinatorial fashion for high throughput screening and optimization. A proof-of-concept device providing 7 combinations (ABC/D, AB/D, BC/D, AC/D, A/D, B/D, and C/D) of 3 additive samples (A, B, and C) into a buffer solution (D) has been demonstrated. Based on mathematical modeling and electrical and computational fluid dynamic simulations, the device has been designed, fabricated and characterized.
KW - Combinatorial dilutiuon
KW - Design of experiments
KW - Drug screening
KW - Microfluidic network
UR - https://www.scopus.com/pages/publications/84901804066
M3 - Conference contribution
AN - SCOPUS:84901804066
SN - 9780979806421
T3 - Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1394
EP - 1396
BT - Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
Y2 - 1 November 2009 through 5 November 2009
ER -