Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies

Dimitrios Farmakiotis; Fazal Shirazi; Yanan Zhao; Peguy J. Saad; Nathaniel D. Albert; Emmanuel Roilides; Thomas J. Walsh; David S. Perlin; Dimitrios P. Kontoyiannis

doi:10.1093/infdis/jiu289

Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies

Dimitrios Farmakiotis
, Fazal Shirazi
, Yanan Zhao
, Peguy J. Saad
, Nathaniel D. Albert
, Emmanuel Roilides
, Thomas J. Walsh
, David S. Perlin
, Dimitrios P. Kontoyiannis

Pharmacy

University of Texas MD Anderson Cancer Center
Aristotle University of Thessaloniki
New York Presbyterian Hospital
Public Health Research Institute, New York

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.

Original language	English
Pages (from-to)	1471-1475
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	210
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiu289
State	Published - Nov 1 2014

Keywords

Animal models
Apoptosis
Corticosteroids
Exserohilum rostratum
Virulence

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10.1093/infdis/jiu289

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Farmakiotis, D., Shirazi, F., Zhao, Y., Saad, P. J., Albert, N. D., Roilides, E., Walsh, T. J., Perlin, D. S., & Kontoyiannis, D. P. (2014). Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies. Journal of Infectious Diseases, 210(9), 1471-1475. https://doi.org/10.1093/infdis/jiu289

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title = "Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies",

abstract = "High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.",

keywords = "Animal models, Apoptosis, Corticosteroids, Exserohilum rostratum, Virulence",

author = "Dimitrios Farmakiotis and Fazal Shirazi and Yanan Zhao and Saad, \{Peguy J.\} and Albert, \{Nathaniel D.\} and Emmanuel Roilides and Walsh, \{Thomas J.\} and Perlin, \{David S.\} and Kontoyiannis, \{Dimitrios P.\}",

year = "2014",

month = nov,

day = "1",

doi = "10.1093/infdis/jiu289",

language = "English",

volume = "210",

pages = "1471--1475",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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}

Farmakiotis, D, Shirazi, F, Zhao, Y, Saad, PJ, Albert, ND, Roilides, E, Walsh, TJ, Perlin, DS & Kontoyiannis, DP 2014, 'Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies', Journal of Infectious Diseases, vol. 210, no. 9, pp. 1471-1475. https://doi.org/10.1093/infdis/jiu289

Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies. / Farmakiotis, Dimitrios; Shirazi, Fazal; Zhao, Yanan et al.
In: Journal of Infectious Diseases, Vol. 210, No. 9, 01.11.2014, p. 1471-1475.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies

AU - Farmakiotis, Dimitrios

AU - Shirazi, Fazal

AU - Zhao, Yanan

AU - Saad, Peguy J.

AU - Albert, Nathaniel D.

AU - Roilides, Emmanuel

AU - Walsh, Thomas J.

AU - Perlin, David S.

AU - Kontoyiannis, Dimitrios P.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.

AB - High concentrations of methylprednisolone (0.32 mg/mL) accelerated growth and attenuated spontaneous apoptosis of Exserohilum rostratum in vitro. Injection of E. rostratum conidia preexposed to 0.32 mg/mL of methylprednisolone for 7 days in immunocompetent flies led to increased mortality and a higher fungal burden. Exposure to methylprednisolone could enhance the virulence of E. rostratum.

KW - Animal models

KW - Apoptosis

KW - Corticosteroids

KW - Exserohilum rostratum

KW - Virulence

UR - https://www.scopus.com/pages/publications/84922041649

U2 - 10.1093/infdis/jiu289

DO - 10.1093/infdis/jiu289

M3 - Article

C2 - 24837401

AN - SCOPUS:84922041649

SN - 0022-1899

VL - 210

SP - 1471

EP - 1475

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 9

ER -

Methylprednisolone enhances the growth of Exserohilum rostratum in vitro, attenuates spontaneous apoptosis, and increases mortality rates in immunocompetent Drosophila flies

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Keywords

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