Methyl 3,4-0-isopropylidene-2-O-(4-methoxybenzyl)-1-thio-β-L-fucopyranoside - a novel, efficient glycosylating reagent for the synthesis of linear and other α-L-fucosyl oligosaccharides

A facile approach toward the synthesis of linear L-fucosyloligosaccharides containing α-L-(1»2) interglycosidic linkages was made possible through the development and utilization of the titled glycosylating reagent. Synthesis of methyl-O-(α-L-fucopyranosyl)-(lα2)-O(α-L-fucopyranosyl)-(1»2)-α-L-fucopyranoside is described. Extended application toward facile and stereoselective synthesis of fucosyl oligosaccharides containing an anomeric p-nitrophenyl or benzyl group is presented.