Mechanisms responsible for reduced in vitro immunoglobulin secretion in aged humans

Jack P. Antel; Joel J.F. Oger; Lawrence G. Wrabetz; Barry G.W. Arnason; John E. Hopper

doi:10.1016/0047-6374(83)90095-7

Mechanisms responsible for reduced in vitro immunoglobulin secretion in aged humans

Jack P. Antel
, Joel J.F. Oger
, Lawrence G. Wrabetz
, Barry G.W. Arnason
, John E. Hopper

Neurology

The University of Chicago
University of Illinois at Chicago

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Age-related changes in the processes involved in T cell dependent polyclonal B cell activation in man were studied by comparing immunoglobulin (Ig) produced in autologous T:B (E⁺:E^-) cell cultures of young and old donor pairs with Ig produced in crossover cultures. Each young and old donor was classified as a responder or a non-responder based on Ig levels in autologous pokeweed mitogen-activated T:B cultures. The data indicate that: (1) T suppressor influences are a major determinant of non-response in the young; (2) T cells of nonresponder old donors can support high levels of Ig secretion by young donors' B cells; (3) low response to pokeweed mitogen stimulation in the elderly may reflect either direct refractoriness of B cells to T cell dependent stimulation, heightened B cell sensitivity to suppressor signals, or a combination of the two.

Original language	English
Pages (from-to)	11-19
Number of pages	9
Journal	Mechanisms of Ageing and Development
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/0047-6374(83)90095-7
State	Published - Sep 1983

Keywords

B cell function
Human aging
Polyclonal immunoglobulin secretion
T suppressor cells

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10.1016/0047-6374(83)90095-7

Cite this

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title = "Mechanisms responsible for reduced in vitro immunoglobulin secretion in aged humans",

abstract = "Age-related changes in the processes involved in T cell dependent polyclonal B cell activation in man were studied by comparing immunoglobulin (Ig) produced in autologous T:B (E+:E-) cell cultures of young and old donor pairs with Ig produced in crossover cultures. Each young and old donor was classified as a responder or a non-responder based on Ig levels in autologous pokeweed mitogen-activated T:B cultures. The data indicate that: (1) T suppressor influences are a major determinant of non-response in the young; (2) T cells of nonresponder old donors can support high levels of Ig secretion by young donors' B cells; (3) low response to pokeweed mitogen stimulation in the elderly may reflect either direct refractoriness of B cells to T cell dependent stimulation, heightened B cell sensitivity to suppressor signals, or a combination of the two.",

keywords = "B cell function, Human aging, Polyclonal immunoglobulin secretion, T suppressor cells",

author = "Antel, \{Jack P.\} and Oger, \{Joel J.F.\} and Wrabetz, \{Lawrence G.\} and Arnason, \{Barry G.W.\} and Hopper, \{John E.\}",

year = "1983",

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TY - JOUR

T1 - Mechanisms responsible for reduced in vitro immunoglobulin secretion in aged humans

AU - Antel, Jack P.

AU - Oger, Joel J.F.

AU - Wrabetz, Lawrence G.

AU - Arnason, Barry G.W.

AU - Hopper, John E.

PY - 1983/9

Y1 - 1983/9

N2 - Age-related changes in the processes involved in T cell dependent polyclonal B cell activation in man were studied by comparing immunoglobulin (Ig) produced in autologous T:B (E+:E-) cell cultures of young and old donor pairs with Ig produced in crossover cultures. Each young and old donor was classified as a responder or a non-responder based on Ig levels in autologous pokeweed mitogen-activated T:B cultures. The data indicate that: (1) T suppressor influences are a major determinant of non-response in the young; (2) T cells of nonresponder old donors can support high levels of Ig secretion by young donors' B cells; (3) low response to pokeweed mitogen stimulation in the elderly may reflect either direct refractoriness of B cells to T cell dependent stimulation, heightened B cell sensitivity to suppressor signals, or a combination of the two.

AB - Age-related changes in the processes involved in T cell dependent polyclonal B cell activation in man were studied by comparing immunoglobulin (Ig) produced in autologous T:B (E+:E-) cell cultures of young and old donor pairs with Ig produced in crossover cultures. Each young and old donor was classified as a responder or a non-responder based on Ig levels in autologous pokeweed mitogen-activated T:B cultures. The data indicate that: (1) T suppressor influences are a major determinant of non-response in the young; (2) T cells of nonresponder old donors can support high levels of Ig secretion by young donors' B cells; (3) low response to pokeweed mitogen stimulation in the elderly may reflect either direct refractoriness of B cells to T cell dependent stimulation, heightened B cell sensitivity to suppressor signals, or a combination of the two.

KW - B cell function

KW - Human aging

KW - Polyclonal immunoglobulin secretion

KW - T suppressor cells

UR - https://www.scopus.com/pages/publications/0021082528

U2 - 10.1016/0047-6374(83)90095-7

DO - 10.1016/0047-6374(83)90095-7

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AN - SCOPUS:0021082528

SN - 0047-6374

VL - 23

SP - 11

EP - 19

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

IS - 1

ER -

Mechanisms responsible for reduced in vitro immunoglobulin secretion in aged humans

Abstract

Keywords

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