Mechanisms of immune regulation by IVIG

Mark Ballow

doi:10.1097/ACI.0000000000000116

Mechanisms of immune regulation by IVIG

Mark Ballow

Pediatrics

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

Many of the mechanisms proposed for the immune-modulating effects of IVIG demonstrate the complexity of immune effector functions in disease processes. Although controversy exists on the role of the FcγRIIB receptor and the importance of the sialylated Fc domain in human autoimmune disorders, probably no one single mechanism is responsible for the effects of IVIG in autoimmune and inflammatory diseases. The potential role of the prostaglandin E pathway may offer alternative treatments.

Original language	English
Pages (from-to)	509-515
Number of pages	7
Journal	Current Opinion in Allergy and Clinical Immunology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1097/ACI.0000000000000116
State	Published - 2014

Keywords

FcγRIIB receptor
Intravenous immune globulin
Neonatal Fc receptor
Prostaglandin E
Sialylation
T-regulatory cells
Th17 cells

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10.1097/ACI.0000000000000116

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abstract = "Many of the mechanisms proposed for the immune-modulating effects of IVIG demonstrate the complexity of immune effector functions in disease processes. Although controversy exists on the role of the FcγRIIB receptor and the importance of the sialylated Fc domain in human autoimmune disorders, probably no one single mechanism is responsible for the effects of IVIG in autoimmune and inflammatory diseases. The potential role of the prostaglandin E pathway may offer alternative treatments.",

keywords = "FcγRIIB receptor, Intravenous immune globulin, Neonatal Fc receptor, Prostaglandin E, Sialylation, T-regulatory cells, Th17 cells",

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AB - Many of the mechanisms proposed for the immune-modulating effects of IVIG demonstrate the complexity of immune effector functions in disease processes. Although controversy exists on the role of the FcγRIIB receptor and the importance of the sialylated Fc domain in human autoimmune disorders, probably no one single mechanism is responsible for the effects of IVIG in autoimmune and inflammatory diseases. The potential role of the prostaglandin E pathway may offer alternative treatments.

KW - FcγRIIB receptor

KW - Intravenous immune globulin

KW - Neonatal Fc receptor

KW - Prostaglandin E

KW - Sialylation

KW - T-regulatory cells

KW - Th17 cells

UR - https://www.scopus.com/pages/publications/84926618863

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M3 - Review article

C2 - 25337683

AN - SCOPUS:84926618863

SN - 1528-4050

VL - 14

SP - 509

EP - 515

JO - Current Opinion in Allergy and Clinical Immunology

JF - Current Opinion in Allergy and Clinical Immunology

IS - 6

ER -

Mechanisms of immune regulation by IVIG

Abstract

Keywords

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