Measurement of smoking topography during withdrawal or deprivation

Smoking behaviors were measured during two methods for changing serum nicotine, providing subjects with high and low nicotine cigarettes, or varying intercigarette intervals. The results showed adjustments in smoking behaviors when cigarettes that vary in nicotine delivery were used, but not when serum nicotine was modified by withdrawal (Exp. 1) or deprivation (Exp. 2). These results suggest inhalation patterns of individual cigarettes may not be sensitive to fluctuations in serum nicotine, while they are sensitive to cigarettes that vary in nicotine yield and draw resistance.