Abstract
We describe a method of using a micro-tip transducer to measure cerebrospinal fluid pressure (CSFp) through a lateral ventricular cannula in unanesthetized, restrained, non-stressed rats. The mean value of CSFp under the anesthesia was 4.2 ± 0.9 (mean ± SEM, n = 6), ranging from 1.3 to 7.5 mmHg. Measurements were made dairy in conscious state for 7 consecutive days after the operation. Mean value of CSFp was 9.1 ± 0.5 mmHg (n - 42), ranging between 8.0 ± 1.4 and 10.4 ± 1.3 mmHg (n = 6) from day to day (P > 0.05). The permanent intraventricular cannula did not cause any detectable changes in behavior, arterial pressure, arterial blood gas, arterial blood acid-base chemistry, and water content of the punctured hemisphere. The results indicated that the method is a reliable alternative for CSFp measurement in a conscious, restrained, non-stressed rat which can be used under a variety of experimental conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 39-43 |
| Number of pages | 5 |
| Journal | Undersea and Hyperbaric Medicine |
| Volume | 24 |
| Issue number | 1 |
| State | Published - Dec 1997 |
Keywords
- Intracranial pressure; cerebrospinal fluid pressure
- Lateral ventricle; animal model
- Rats
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