Maximal daily dose of pancreatic enzyme replacement therapy in infants with cystic fibrosis: A reconsideration

Drucy Borowitz; Daniel Gelfond; Karen Maguiness; James E. Heubi; Bonnie Ramsey

doi:10.1016/j.jcf.2013.05.011

Maximal daily dose of pancreatic enzyme replacement therapy in infants with cystic fibrosis: A reconsideration

Drucy Borowitz
, Daniel Gelfond
, Karen Maguiness
, James E. Heubi
, Bonnie Ramsey

Pediatrics

SUNY Buffalo
Riley Hospital for Children
University of Cincinnati
University of Washington

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The current recommendations for dosing of pancreatic enzyme replacement therapy (PERT) in infants with cystic fibrosis (CF) were made using a limited evidence base. The per meal recommended dose was extrapolated from dosing guidelines for older patients into a maximal daily dose for infants. We discuss why this maximal daily dose recommendation may be insufficient for young infants with CF, although the optimal dose of PERT for infants with CF remains unknown.

Original language	English
Pages (from-to)	784-785
Number of pages	2
Journal	Journal of Cystic Fibrosis
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.jcf.2013.05.011
State	Published - Dec 2013

Keywords

Cystic fibrosis
Infant nutrition
Pancreatic enzymes
Pancreatic insufficiency

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10.1016/j.jcf.2013.05.011

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abstract = "The current recommendations for dosing of pancreatic enzyme replacement therapy (PERT) in infants with cystic fibrosis (CF) were made using a limited evidence base. The per meal recommended dose was extrapolated from dosing guidelines for older patients into a maximal daily dose for infants. We discuss why this maximal daily dose recommendation may be insufficient for young infants with CF, although the optimal dose of PERT for infants with CF remains unknown.",

keywords = "Cystic fibrosis, Infant nutrition, Pancreatic enzymes, Pancreatic insufficiency",

author = "Drucy Borowitz and Daniel Gelfond and Karen Maguiness and Heubi, \{James E.\} and Bonnie Ramsey",

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AU - Borowitz, Drucy

AU - Gelfond, Daniel

AU - Maguiness, Karen

AU - Heubi, James E.

AU - Ramsey, Bonnie

PY - 2013/12

Y1 - 2013/12

N2 - The current recommendations for dosing of pancreatic enzyme replacement therapy (PERT) in infants with cystic fibrosis (CF) were made using a limited evidence base. The per meal recommended dose was extrapolated from dosing guidelines for older patients into a maximal daily dose for infants. We discuss why this maximal daily dose recommendation may be insufficient for young infants with CF, although the optimal dose of PERT for infants with CF remains unknown.

AB - The current recommendations for dosing of pancreatic enzyme replacement therapy (PERT) in infants with cystic fibrosis (CF) were made using a limited evidence base. The per meal recommended dose was extrapolated from dosing guidelines for older patients into a maximal daily dose for infants. We discuss why this maximal daily dose recommendation may be insufficient for young infants with CF, although the optimal dose of PERT for infants with CF remains unknown.

KW - Cystic fibrosis

KW - Infant nutrition

KW - Pancreatic enzymes

KW - Pancreatic insufficiency

UR - https://www.scopus.com/pages/publications/84888068385

U2 - 10.1016/j.jcf.2013.05.011

DO - 10.1016/j.jcf.2013.05.011

M3 - Article

C2 - 23809508

AN - SCOPUS:84888068385

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VL - 12

SP - 784

EP - 785

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - 6

ER -

Maximal daily dose of pancreatic enzyme replacement therapy in infants with cystic fibrosis: A reconsideration

Abstract

Keywords

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