TY - JOUR
T1 - Maternal and Pediatric Precision in Therapeutic Knowledge Portal (MPRINT-KP)
T2 - Landscape Analysis of Pharmacology Research in Maternal and Pediatric Patient Populations
AU - Liu, Xiaofu
AU - Shendre, Aditi
AU - Wang, Lei
AU - O'Kane, Aislinn
AU - Ma, Hanson
AU - Chiang, Chien Wei
AU - Zaidi, Syed S.
AU - Aboshady, Omar A.
AU - So, Gerald
AU - Tillman, Emma M.
AU - Kirkpatrick, Lindsey M.
AU - Costantine, Maged
AU - Grannis, Shaun
AU - Rogerson, Colin M.
AU - Bartlett, Christopher
AU - Rahurkar, Saurabh
AU - Cheng, Lijun
AU - Ouyang, Jiayi
AU - Wei, Ping
AU - Zhu, Zhimo
AU - Li, Shangjia
AU - Huang, Yirui
AU - Wang, Lingling
AU - Cao, Weidan
AU - Jiang, Haoran
AU - Liu, Jianing
AU - Oteng, Samuel Richard
AU - Goodwin, Andrew
AU - Deypalubos, Jiezel Ann Faith
AU - Zhang, Shijun
AU - Bies, Robert
AU - Quinney, Sara K.
AU - Li, Lang
N1 - Publisher Copyright:
© 2026 The Author(s). Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy published by Wiley Periodicals LLC on behalf of ACCP Foundation, Ltd.
PY - 2026/3
Y1 - 2026/3
N2 - Pregnant women and children have been underrepresented in clinical studies due to ethical concerns and perceived vulnerabilities. This resulted in a significant gap in knowledge regarding the safety and efficacy of medications for these populations. Maternal and Pediatric PRecision In Therapeutics Knowledge Portal (MPRINT-KP) is designed to provide a comprehensive view of pharmacokinetic, pharmaco-epidemiology, and clinical trial research evidence in maternal and pediatric patient populations. MPRINT-KP Silver was generated upon BioBERT models, due to their supreme performance in classifying pharmacokinetic, pharmaco-epidemiology, and clinical trial papers from PubMed, with an F1-score > 0.91. As of April 1, 2025, MPRINT-KP Silver contains 758,560 clinical pharmacology research papers in maternal and pediatric populations. The landscape analysis revealed a large number of drugs with pharmacology knowledge gaps, which is calculated as the relative frequency of drugs with no or weak (i.e., less than five publications) evidence in each of pharmacokinetic, pharmaco-epidemiology, or clinical trial study type. The highest pharmacotherapy knowledge gaps are in postpartum women, pregnant women, and pediatric patients between 0–12 and 12–18 years of age (51.37%, 32.47%, 25.82%, 32.11%, respectively). Pharmacovigilance analyses were conducted on highly prescribed drugs with limited pharmacology evidence in pediatric patients 0–2 year old and pregnant women using United States Food and Drug Administration Adverse Event Reporting System (FAERS) and MarketScan claims data. A number of new drug-associated adverse drug events (ADEs) were discovered. In pediatric patients, there were crisaborole-associated hemorrhage and moxifloxacin-associated cardiac toxicities. In pregnant women, the analysis revealed terconazole-associated abnormalities of heartbeat; benzonatate-associated depressive and anxiety disorders; buspirone-associated abnormalities of heartbeat; cyclobenzaprine-associated tubulo-interstitial nephritis; and pantoprazole-associated hearing loss and voice and resonance disorders. For the first time, a large-scale landscape analysis of pharmacotherapy knowledge gap in both maternal and pediatric patient populations was conducted and identified new drug associated ADE evidence using real world data.
AB - Pregnant women and children have been underrepresented in clinical studies due to ethical concerns and perceived vulnerabilities. This resulted in a significant gap in knowledge regarding the safety and efficacy of medications for these populations. Maternal and Pediatric PRecision In Therapeutics Knowledge Portal (MPRINT-KP) is designed to provide a comprehensive view of pharmacokinetic, pharmaco-epidemiology, and clinical trial research evidence in maternal and pediatric patient populations. MPRINT-KP Silver was generated upon BioBERT models, due to their supreme performance in classifying pharmacokinetic, pharmaco-epidemiology, and clinical trial papers from PubMed, with an F1-score > 0.91. As of April 1, 2025, MPRINT-KP Silver contains 758,560 clinical pharmacology research papers in maternal and pediatric populations. The landscape analysis revealed a large number of drugs with pharmacology knowledge gaps, which is calculated as the relative frequency of drugs with no or weak (i.e., less than five publications) evidence in each of pharmacokinetic, pharmaco-epidemiology, or clinical trial study type. The highest pharmacotherapy knowledge gaps are in postpartum women, pregnant women, and pediatric patients between 0–12 and 12–18 years of age (51.37%, 32.47%, 25.82%, 32.11%, respectively). Pharmacovigilance analyses were conducted on highly prescribed drugs with limited pharmacology evidence in pediatric patients 0–2 year old and pregnant women using United States Food and Drug Administration Adverse Event Reporting System (FAERS) and MarketScan claims data. A number of new drug-associated adverse drug events (ADEs) were discovered. In pediatric patients, there were crisaborole-associated hemorrhage and moxifloxacin-associated cardiac toxicities. In pregnant women, the analysis revealed terconazole-associated abnormalities of heartbeat; benzonatate-associated depressive and anxiety disorders; buspirone-associated abnormalities of heartbeat; cyclobenzaprine-associated tubulo-interstitial nephritis; and pantoprazole-associated hearing loss and voice and resonance disorders. For the first time, a large-scale landscape analysis of pharmacotherapy knowledge gap in both maternal and pediatric patient populations was conducted and identified new drug associated ADE evidence using real world data.
KW - artificial intelligence
KW - clinical trials as topic
KW - knowledge bases
KW - maternal-child nursing
KW - pharmacoepidemiology
KW - pharmacokinetics
KW - therapeutics
UR - https://www.scopus.com/pages/publications/105030666836
U2 - 10.1002/phar.70096
DO - 10.1002/phar.70096
M3 - Review article
C2 - 41730795
AN - SCOPUS:105030666836
SN - 0277-0008
VL - 46
JO - Pharmacotherapy
JF - Pharmacotherapy
IS - 3
M1 - e70096
ER -