Manipulating the gut microbiome to decrease uremic toxins

Rabi Yacoub; Christina M. Wyatt

doi:10.1016/j.kint.2017.01.003

Manipulating the gut microbiome to decrease uremic toxins

Rabi Yacoub
, Christina M. Wyatt

Medicine

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Comment/debate

33 Scopus citations

Abstract

The uremic solute indoxyl sulfate has been associated with increased mortality and other adverse outcomes in patients with chronic kidney disease. In a recent study published in Cell Host & Microbe, Devlin et al. describe a novel approach to alter the production of indoxyl sulfate through manipulation of the gut microbiota. Although this approach is far from clinical application, it may allow investigators to determine the contribution of uremic solutes to disease pathogenesis.

Original language	English
Pages (from-to)	521-523
Number of pages	3
Journal	Kidney International
Volume	91
Issue number	3
DOIs	https://doi.org/10.1016/j.kint.2017.01.003
State	Published - Mar 1 2017

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10.1016/j.kint.2017.01.003

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title = "Manipulating the gut microbiome to decrease uremic toxins",

abstract = "The uremic solute indoxyl sulfate has been associated with increased mortality and other adverse outcomes in patients with chronic kidney disease. In a recent study published in Cell Host \& Microbe, Devlin et al. describe a novel approach to alter the production of indoxyl sulfate through manipulation of the gut microbiota. Although this approach is far from clinical application, it may allow investigators to determine the contribution of uremic solutes to disease pathogenesis.",

author = "Rabi Yacoub and Wyatt, \{Christina M.\}",

note = "Publisher Copyright: {\textcopyright} 2017 International Society of Nephrology",

year = "2017",

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AU - Yacoub, Rabi

AU - Wyatt, Christina M.

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N2 - The uremic solute indoxyl sulfate has been associated with increased mortality and other adverse outcomes in patients with chronic kidney disease. In a recent study published in Cell Host & Microbe, Devlin et al. describe a novel approach to alter the production of indoxyl sulfate through manipulation of the gut microbiota. Although this approach is far from clinical application, it may allow investigators to determine the contribution of uremic solutes to disease pathogenesis.

AB - The uremic solute indoxyl sulfate has been associated with increased mortality and other adverse outcomes in patients with chronic kidney disease. In a recent study published in Cell Host & Microbe, Devlin et al. describe a novel approach to alter the production of indoxyl sulfate through manipulation of the gut microbiota. Although this approach is far from clinical application, it may allow investigators to determine the contribution of uremic solutes to disease pathogenesis.

UR - https://www.scopus.com/pages/publications/85012965315

U2 - 10.1016/j.kint.2017.01.003

DO - 10.1016/j.kint.2017.01.003

M3 - Comment/debate

C2 - 28202164

AN - SCOPUS:85012965315

SN - 0085-2538

VL - 91

SP - 521

EP - 523

JO - Kidney International

JF - Kidney International

IS - 3

ER -

Manipulating the gut microbiome to decrease uremic toxins

Abstract

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