Manipulating memory in space and time

Dheeraj S. Roy; Susumu Tonegawa

doi:10.1016/j.cobeha.2017.05.020

Manipulating memory in space and time

Dheeraj S. Roy
, Susumu Tonegawa

Physiology and Biophysics

Massachusetts Institute of Technology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

One of the most fascinating aspects of an animal's brain is its ability to acquire new information from experience and retain this information over time as memory. The search for physical correlates of memory, the memory engram, has been a longstanding endeavor in modern neurobiology. Recent advances in transgenic and optogenetic tools have enabled the identification, visualization, and manipulations of natural, sensory-evoked, engram cells for a specific memory residing in specific brain regions. These studies are paving the way not only to understand memory mechanisms in unprecedented detail, but also to repair the abnormal state of mind associated with memory by engineering.

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Current Opinion in Behavioral Sciences
Volume	17
DOIs	https://doi.org/10.1016/j.cobeha.2017.05.020
State	Published - Oct 2017

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10.1016/j.cobeha.2017.05.020

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abstract = "One of the most fascinating aspects of an animal's brain is its ability to acquire new information from experience and retain this information over time as memory. The search for physical correlates of memory, the memory engram, has been a longstanding endeavor in modern neurobiology. Recent advances in transgenic and optogenetic tools have enabled the identification, visualization, and manipulations of natural, sensory-evoked, engram cells for a specific memory residing in specific brain regions. These studies are paving the way not only to understand memory mechanisms in unprecedented detail, but also to repair the abnormal state of mind associated with memory by engineering.",

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AB - One of the most fascinating aspects of an animal's brain is its ability to acquire new information from experience and retain this information over time as memory. The search for physical correlates of memory, the memory engram, has been a longstanding endeavor in modern neurobiology. Recent advances in transgenic and optogenetic tools have enabled the identification, visualization, and manipulations of natural, sensory-evoked, engram cells for a specific memory residing in specific brain regions. These studies are paving the way not only to understand memory mechanisms in unprecedented detail, but also to repair the abnormal state of mind associated with memory by engineering.

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U2 - 10.1016/j.cobeha.2017.05.020

DO - 10.1016/j.cobeha.2017.05.020

M3 - Review article

AN - SCOPUS:85020204865

SN - 2352-1546

VL - 17

SP - 1

EP - 6

JO - Current Opinion in Behavioral Sciences

JF - Current Opinion in Behavioral Sciences

ER -

Manipulating memory in space and time

Abstract

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