Manganese homeostasis and transport

Jerome Roth; Silvia Ponzoni; Michael Aschner

doi:10.1007/978-94-007-5561-1_6

Manganese homeostasis and transport

Jerome Roth
, Silvia Ponzoni
, Michael Aschner

Pharmacology and Toxicology

Universidade Estadual de Londrina
Vanderbilt University

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.

Original language	English
Pages (from-to)	169-201
Number of pages	33
Journal	Metal Ions in Life Sciences
Volume	12
DOIs	https://doi.org/10.1007/978-94-007-5561-1_6
State	Published - 2013

Keywords

Divalent metal transporter 1 (DMT1)
Manganese
Mitochondria
Parkin
Transport

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10.1007/978-94-007-5561-1_6

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title = "Manganese homeostasis and transport",

abstract = "The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.",

keywords = "Divalent metal transporter 1 (DMT1), Manganese, Mitochondria, Parkin, Transport",

author = "Jerome Roth and Silvia Ponzoni and Michael Aschner",

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T1 - Manganese homeostasis and transport

AU - Roth, Jerome

AU - Ponzoni, Silvia

AU - Aschner, Michael

PY - 2013

Y1 - 2013

N2 - The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.

AB - The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.

KW - Divalent metal transporter 1 (DMT1)

KW - Manganese

KW - Mitochondria

KW - Parkin

KW - Transport

UR - https://www.scopus.com/pages/publications/84893871311

U2 - 10.1007/978-94-007-5561-1_6

DO - 10.1007/978-94-007-5561-1_6

M3 - Article

C2 - 23595673

AN - SCOPUS:84893871311

SN - 1559-0836

VL - 12

SP - 169

EP - 201

JO - Metal Ions in Life Sciences

JF - Metal Ions in Life Sciences

ER -

Manganese homeostasis and transport

Abstract

Keywords

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