TY - GEN
T1 - Magnetoplasmonic nanoplatforms for enhanced bioimaging and photothermal cancer therapy
AU - Kopwitthaya, A.
AU - Ohulchanskyy, T. Y.
AU - Jeon, M.
AU - Law, W. C.
AU - Xue, X.
AU - Xie, Q.
AU - Chada, R. R.
AU - Furlani, E. P.
AU - Kim, C.
AU - Prasad, P. N.
PY - 2012
Y1 - 2012
N2 - In this presentation we introduce a novel magnetoplasmonic nanoplatform for biomedical applications. The nanoplatform consists of a gold nanorod (GNR) and multiple Fe 3O 4 nanoparticles enclosed in a polymeric micelle-like structure. The combined magnetic and plasmonic functionality of the nanoplatform enables field-directed targeting, enhanced multimodal imaging, and therapy of diseased tissue. We demonstrate magnetophoretic control of the nanoformulations in vitro wherein an external field is used to accelerate uptake and aggregate the nanoplatforms in cancer cells. Following uptake, the nanoplatforms are illuminated with the femtosecond-pulsed IR laser, which causes photothermal destruction of the cells due to plasmonically-enhanced heating and bubble generation. We show that field-induced aggregation dramatically enhances the ability to selectively destroy targeted cells compared to the same therapy in the absence of a field. We also demonstrate that magnetically aggregated nanoplatforms produce enhanced photoacoustic tomography (PAT).
AB - In this presentation we introduce a novel magnetoplasmonic nanoplatform for biomedical applications. The nanoplatform consists of a gold nanorod (GNR) and multiple Fe 3O 4 nanoparticles enclosed in a polymeric micelle-like structure. The combined magnetic and plasmonic functionality of the nanoplatform enables field-directed targeting, enhanced multimodal imaging, and therapy of diseased tissue. We demonstrate magnetophoretic control of the nanoformulations in vitro wherein an external field is used to accelerate uptake and aggregate the nanoplatforms in cancer cells. Following uptake, the nanoplatforms are illuminated with the femtosecond-pulsed IR laser, which causes photothermal destruction of the cells due to plasmonically-enhanced heating and bubble generation. We show that field-induced aggregation dramatically enhances the ability to selectively destroy targeted cells compared to the same therapy in the absence of a field. We also demonstrate that magnetically aggregated nanoplatforms produce enhanced photoacoustic tomography (PAT).
KW - LSPR-induced absorption
KW - Magnetoplasmonic nanoplatform
KW - Photoacoustic tomography
KW - Photothermal cancer therapy
KW - Plasmonic enhanced bubble nucleation
UR - https://www.scopus.com/pages/publications/84865007431
M3 - Conference contribution
AN - SCOPUS:84865007431
SN - 9781466562769
T3 - Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
SP - 32
EP - 35
BT - Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
T2 - Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
Y2 - 18 June 2012 through 21 June 2012
ER -