Magnetic Resonance Imaging and Analysis in Multiple Sclerosis

Dejan Jakimovski; Deepa P. Ramasamy; Robert Zivadinov

doi:10.1007/978-3-030-24436-1_6

Magnetic Resonance Imaging and Analysis in Multiple Sclerosis

Dejan Jakimovski
, Deepa P. Ramasamy
, Robert Zivadinov

Neurology

SUNY Buffalo

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

6 Scopus citations

Abstract

Conventional magnetic resonance imaging (MRI) has become an established and routine examination in multiple sclerosis (MS) patients. Currently, the MRI-derived metrics are the most sensitive diagnostic and prognostic biomarkers for MS patients. The accumulating evidence of previously undetected widespread disease activity and progressive neurodegeneration emphasizes the need for better understanding of the disease pathophysiology. This review addresses the significance of a large variety of nonconventional MRI techniques including measurement of brain atrophy, use of iron-based contrast agents, magnetization transfer imaging (MTI), diffusion-tensor imaging (DTI), susceptibility-weighted imaging (SWI), functional MRI (fMRI), MR spectroscopy (MRS), and quantitative MRI (qMRI). Their future perspectives in use for clinical MS and new drug discovery are also discussed. Before clinical implementation of the nonconventional MRI modalities, further standardization is still warranted.

Original language	English
Title of host publication	Current Clinical Neurology
Publisher	Humana Press Inc.
Pages	109-136
Number of pages	28
DOIs	https://doi.org/10.1007/978-3-030-24436-1_6
State	Published - 2020

Publication series

Name	Current Clinical Neurology
ISSN (Print)	1559-0585
ISSN (Electronic)	2524-4043

Keywords

DTI
fMRI
MRI
MRS
MTI
Multiple sclerosis
QSM

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10.1007/978-3-030-24436-1_6

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title = "Magnetic Resonance Imaging and Analysis in Multiple Sclerosis",

abstract = "Conventional magnetic resonance imaging (MRI) has become an established and routine examination in multiple sclerosis (MS) patients. Currently, the MRI-derived metrics are the most sensitive diagnostic and prognostic biomarkers for MS patients. The accumulating evidence of previously undetected widespread disease activity and progressive neurodegeneration emphasizes the need for better understanding of the disease pathophysiology. This review addresses the significance of a large variety of nonconventional MRI techniques including measurement of brain atrophy, use of iron-based contrast agents, magnetization transfer imaging (MTI), diffusion-tensor imaging (DTI), susceptibility-weighted imaging (SWI), functional MRI (fMRI), MR spectroscopy (MRS), and quantitative MRI (qMRI). Their future perspectives in use for clinical MS and new drug discovery are also discussed. Before clinical implementation of the nonconventional MRI modalities, further standardization is still warranted.",

keywords = "DTI, fMRI, MRI, MRS, MTI, Multiple sclerosis, QSM",

author = "Dejan Jakimovski and Ramasamy, \{Deepa P.\} and Robert Zivadinov",

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year = "2020",

doi = "10.1007/978-3-030-24436-1\_6",

language = "English",

series = "Current Clinical Neurology",

publisher = "Humana Press Inc.",

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TY - CHAP

T1 - Magnetic Resonance Imaging and Analysis in Multiple Sclerosis

AU - Jakimovski, Dejan

AU - Ramasamy, Deepa P.

AU - Zivadinov, Robert

PY - 2020

Y1 - 2020

N2 - Conventional magnetic resonance imaging (MRI) has become an established and routine examination in multiple sclerosis (MS) patients. Currently, the MRI-derived metrics are the most sensitive diagnostic and prognostic biomarkers for MS patients. The accumulating evidence of previously undetected widespread disease activity and progressive neurodegeneration emphasizes the need for better understanding of the disease pathophysiology. This review addresses the significance of a large variety of nonconventional MRI techniques including measurement of brain atrophy, use of iron-based contrast agents, magnetization transfer imaging (MTI), diffusion-tensor imaging (DTI), susceptibility-weighted imaging (SWI), functional MRI (fMRI), MR spectroscopy (MRS), and quantitative MRI (qMRI). Their future perspectives in use for clinical MS and new drug discovery are also discussed. Before clinical implementation of the nonconventional MRI modalities, further standardization is still warranted.

AB - Conventional magnetic resonance imaging (MRI) has become an established and routine examination in multiple sclerosis (MS) patients. Currently, the MRI-derived metrics are the most sensitive diagnostic and prognostic biomarkers for MS patients. The accumulating evidence of previously undetected widespread disease activity and progressive neurodegeneration emphasizes the need for better understanding of the disease pathophysiology. This review addresses the significance of a large variety of nonconventional MRI techniques including measurement of brain atrophy, use of iron-based contrast agents, magnetization transfer imaging (MTI), diffusion-tensor imaging (DTI), susceptibility-weighted imaging (SWI), functional MRI (fMRI), MR spectroscopy (MRS), and quantitative MRI (qMRI). Their future perspectives in use for clinical MS and new drug discovery are also discussed. Before clinical implementation of the nonconventional MRI modalities, further standardization is still warranted.

KW - DTI

KW - fMRI

KW - MRI

KW - MRS

KW - MTI

KW - Multiple sclerosis

KW - QSM

UR - https://www.scopus.com/pages/publications/85074647285

U2 - 10.1007/978-3-030-24436-1_6

DO - 10.1007/978-3-030-24436-1_6

M3 - Chapter

AN - SCOPUS:85074647285

T3 - Current Clinical Neurology

SP - 109

EP - 136

BT - Current Clinical Neurology

PB - Humana Press Inc.

ER -

Magnetic Resonance Imaging and Analysis in Multiple Sclerosis

Abstract

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Keywords

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