Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density

Brian T. Tsuji; Yoriko Harigaya; Alan J. Lesse; George Sakoulas; Joseph M. Mylotte

doi:10.1016/j.diagmicrobio.2009.01.028

Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density

Brian T. Tsuji
, Yoriko Harigaya
, Alan J. Lesse
, George Sakoulas
, Joseph M. Mylotte

SUNY Buffalo
New York Medical College
Sharp Healthcare

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The impact of accessory gene regulator (agr) dysfunction and high bacterial density on vancomycin killing and resistance was evaluated among 10 clinical methicillin-resistant Staphylococcus aureus bloodstream isolates using time kill experiments. Under conditions of high inocula and agr dysfunction, vancomycin activity was markedly attenuated, amplifying resistant mutants by 72 h.

Original language	English
Pages (from-to)	220-224
Number of pages	5
Journal	Diagnostic Microbiology and Infectious Disease
Volume	64
Issue number	2
DOIs	https://doi.org/10.1016/j.diagmicrobio.2009.01.028
State	Published - Jun 2009

Keywords

Accessory gene regulator
Bloodstream infection
Staphylococcus aureus
Vancomycin

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10.1016/j.diagmicrobio.2009.01.028

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title = "Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density",

abstract = "The impact of accessory gene regulator (agr) dysfunction and high bacterial density on vancomycin killing and resistance was evaluated among 10 clinical methicillin-resistant Staphylococcus aureus bloodstream isolates using time kill experiments. Under conditions of high inocula and agr dysfunction, vancomycin activity was markedly attenuated, amplifying resistant mutants by 72 h.",

keywords = "Accessory gene regulator, Bloodstream infection, Staphylococcus aureus, Vancomycin",

author = "Tsuji, \{Brian T.\} and Yoriko Harigaya and Lesse, \{Alan J.\} and George Sakoulas and Mylotte, \{Joseph M.\}",

year = "2009",

month = jun,

doi = "10.1016/j.diagmicrobio.2009.01.028",

language = "English",

volume = "64",

pages = "220--224",

journal = "Diagnostic Microbiology and Infectious Disease",

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}

Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density. / Tsuji, Brian T.; Harigaya, Yoriko; Lesse, Alan J. et al.
In: Diagnostic Microbiology and Infectious Disease, Vol. 64, No. 2, 06.2009, p. 220-224.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density

AU - Tsuji, Brian T.

AU - Harigaya, Yoriko

AU - Lesse, Alan J.

AU - Sakoulas, George

AU - Mylotte, Joseph M.

PY - 2009/6

Y1 - 2009/6

N2 - The impact of accessory gene regulator (agr) dysfunction and high bacterial density on vancomycin killing and resistance was evaluated among 10 clinical methicillin-resistant Staphylococcus aureus bloodstream isolates using time kill experiments. Under conditions of high inocula and agr dysfunction, vancomycin activity was markedly attenuated, amplifying resistant mutants by 72 h.

AB - The impact of accessory gene regulator (agr) dysfunction and high bacterial density on vancomycin killing and resistance was evaluated among 10 clinical methicillin-resistant Staphylococcus aureus bloodstream isolates using time kill experiments. Under conditions of high inocula and agr dysfunction, vancomycin activity was markedly attenuated, amplifying resistant mutants by 72 h.

KW - Accessory gene regulator

KW - Bloodstream infection

KW - Staphylococcus aureus

KW - Vancomycin

UR - https://www.scopus.com/pages/publications/67349128581

U2 - 10.1016/j.diagmicrobio.2009.01.028

DO - 10.1016/j.diagmicrobio.2009.01.028

M3 - Article

C2 - 19345040

AN - SCOPUS:67349128581

SN - 0732-8893

VL - 64

SP - 220

EP - 224

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 2

ER -

Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density

Abstract

Keywords

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